Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer
Background: Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn considerable attention due to its therapeutic potential, particularly its anticancer properties. It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conven...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001957 |
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| author | Abhishek Chauhan Hemant Joshi Divya Kandari Diwakar Aggarwal Ritu Chauhan Hardeep Singh Tuli Arpit Mehrotra Abhilasha Sood Ujjawal Sharma Darin Mansor Mathkor Shafiul Haque Naveen Chandra Joshi Laurent Dufossé |
| author_facet | Abhishek Chauhan Hemant Joshi Divya Kandari Diwakar Aggarwal Ritu Chauhan Hardeep Singh Tuli Arpit Mehrotra Abhilasha Sood Ujjawal Sharma Darin Mansor Mathkor Shafiul Haque Naveen Chandra Joshi Laurent Dufossé |
| author_sort | Abhishek Chauhan |
| collection | DOAJ |
| description | Background: Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn considerable attention due to its therapeutic potential, particularly its anticancer properties. It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conventional chemotherapeutics by modulating key signaling pathways like PI3K/AKT, MAPKs, and NF-κB. Purpose: This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells. Methods: A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. Keywords such as ''Oridonin,'' ''Apoptosis,'' ''Cancer Cell Signaling Pathways,'' ''PI3K/AKT,'' ''ROS,'' and ''Nanotechnology'' were used, yielding 96 relevant studies. Results: Oridonin induces apoptosis through intrinsic and extrinsic pathways, involving ROS amplification and mitochondrial membrane potential regulation. It modulates proteins like Bax, Bcl-2, cytochrome c, and caspases, leading to DNA fragmentation. Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential. Conclusion: Oridonin demonstrates robust anticancer activity by modulating signaling pathways and inducing apoptosis. Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative. |
| format | Article |
| id | doaj-art-ea1f62082a5348ec8ab0535091ecf2e8 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-ea1f62082a5348ec8ab0535091ecf2e82025-02-10T04:35:17ZengElsevierPhytomedicine Plus2667-03132025-02-0151100721Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancerAbhishek Chauhan0Hemant Joshi1Divya Kandari2Diwakar Aggarwal3Ritu Chauhan4Hardeep Singh Tuli5Arpit Mehrotra6Abhilasha Sood7Ujjawal Sharma8Darin Mansor Mathkor9Shafiul Haque10Naveen Chandra Joshi11Laurent Dufossé12Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida, 201303, IndiaSchool of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, IndiaSchool of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, IndiaDepartment of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala 133207, IndiaDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun 248002, Uttarakhand, IndiaDepartment of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Punjab, India; Corresponding authors.Department of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Punjab, IndiaDepartment of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Punjab, IndiaDepartment of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Punjab, Bathinda, 151401, IndiaResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi ArabiaResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; Gilbert and Rose-Marie Chagoury, School of Medicine, Lebanese American University, Beirut 1102 2801, LebanonAmity Institute of Microbial Technology, Amity University, Noida 201313, IndiaChemistry and Biotechnology of Natural Products, CHEMBIOPRO, Université de La Réunion, ESIROI Agroalimentaire, 15 Avenue René Cassin, CS 92003, CEDEX 9, F-97744 Saint-Denis, France; Corresponding authors.Background: Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn considerable attention due to its therapeutic potential, particularly its anticancer properties. It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conventional chemotherapeutics by modulating key signaling pathways like PI3K/AKT, MAPKs, and NF-κB. Purpose: This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells. Methods: A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. Keywords such as ''Oridonin,'' ''Apoptosis,'' ''Cancer Cell Signaling Pathways,'' ''PI3K/AKT,'' ''ROS,'' and ''Nanotechnology'' were used, yielding 96 relevant studies. Results: Oridonin induces apoptosis through intrinsic and extrinsic pathways, involving ROS amplification and mitochondrial membrane potential regulation. It modulates proteins like Bax, Bcl-2, cytochrome c, and caspases, leading to DNA fragmentation. Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential. Conclusion: Oridonin demonstrates robust anticancer activity by modulating signaling pathways and inducing apoptosis. Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.http://www.sciencedirect.com/science/article/pii/S2667031324001957OridoninTerpenoidsCancerApoptosisCell signaling |
| spellingShingle | Abhishek Chauhan Hemant Joshi Divya Kandari Diwakar Aggarwal Ritu Chauhan Hardeep Singh Tuli Arpit Mehrotra Abhilasha Sood Ujjawal Sharma Darin Mansor Mathkor Shafiul Haque Naveen Chandra Joshi Laurent Dufossé Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer Phytomedicine Plus Oridonin Terpenoids Cancer Apoptosis Cell signaling |
| title | Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| title_full | Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| title_fullStr | Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| title_full_unstemmed | Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| title_short | Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| title_sort | oridonin a natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer |
| topic | Oridonin Terpenoids Cancer Apoptosis Cell signaling |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001957 |
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