Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis.
<h4>Background</h4>In-stent restenosis (ISR) remains a significant challenge despite advancements in percutaneous interventions, often leading to adverse clinical outcomes. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential biomarker for predicting ISR, offering opportun...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0322461 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850123229365010432 |
|---|---|
| author | Paulus Parholong Siahaan Wynne Widiarti Pandit Bagus Tri Saputra Rendra Mahardhika Putra Mario D'Oria |
| author_facet | Paulus Parholong Siahaan Wynne Widiarti Pandit Bagus Tri Saputra Rendra Mahardhika Putra Mario D'Oria |
| author_sort | Paulus Parholong Siahaan |
| collection | DOAJ |
| description | <h4>Background</h4>In-stent restenosis (ISR) remains a significant challenge despite advancements in percutaneous interventions, often leading to adverse clinical outcomes. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential biomarker for predicting ISR, offering opportunities for improved risk stratification and treatment personalization. This systematic review and meta-analysis assess the predictive value of NLR in ISR, providing insights into its clinical applicability.<h4>Methods</h4>Systematic literature search was conducted in scientific databases until 21st July 2024. Observational studies evaluating NLR in stented patients were included. Random effect meta-analysis and linear regression model were used to investigate odds ratios (OR) as predictor and linear dose-response relationship of ISR. Sensitivity and specificity of NLR to predict this outcome were pooled and a summary receiver operating characteristics (sROC) curve was generated. This study was already registered in the PROSPERO (ID: CRD42024555123).<h4>Results</h4>15 studies with 3 889 patients were included. High NLR was associated with increased risk of ISR in coronary and non-coronary stenting [aOR = 1.61 (95%CI 1.14-2.25); aOR = 1.69 (95%CI 1.52-1.87)]. One unit increase of NLR is equal to 30% and 44% increased risk of ISR in coronary and non-coronary patients. Included studies showing NLR as a robust predictor of ISR with sensitivity and specificity of 70.5% (95%CI 60.1%-79.2%) and 74.1% (95%CI 56.7%-86.2%) for coronary stenting and 77.7% (95%CI 69.8%-84.0%) and 66.4% (95%CI 49.6%-79.8%) non-coronary stenting, with AUC of 0.77 (0.70-0.82) in the coronary and 0.79 (0.70-0.85) in the non-coronary sub-groups.<h4>Conclusion</h4>In conclusion, NLR yields promising predictive and prognostic potentials in predicting ISR in coronary and non-coronary stents. Additionally, NLR appears to be more proficient in predicting early ISR compared to late ISR in both coronary and non-coronary stents. |
| format | Article |
| id | doaj-art-ea18a84650964c9b935d0f1daff98daf |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ea18a84650964c9b935d0f1daff98daf2025-08-20T02:34:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032246110.1371/journal.pone.0322461Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis.Paulus Parholong SiahaanWynne WidiartiPandit Bagus Tri SaputraRendra Mahardhika PutraMario D'Oria<h4>Background</h4>In-stent restenosis (ISR) remains a significant challenge despite advancements in percutaneous interventions, often leading to adverse clinical outcomes. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential biomarker for predicting ISR, offering opportunities for improved risk stratification and treatment personalization. This systematic review and meta-analysis assess the predictive value of NLR in ISR, providing insights into its clinical applicability.<h4>Methods</h4>Systematic literature search was conducted in scientific databases until 21st July 2024. Observational studies evaluating NLR in stented patients were included. Random effect meta-analysis and linear regression model were used to investigate odds ratios (OR) as predictor and linear dose-response relationship of ISR. Sensitivity and specificity of NLR to predict this outcome were pooled and a summary receiver operating characteristics (sROC) curve was generated. This study was already registered in the PROSPERO (ID: CRD42024555123).<h4>Results</h4>15 studies with 3 889 patients were included. High NLR was associated with increased risk of ISR in coronary and non-coronary stenting [aOR = 1.61 (95%CI 1.14-2.25); aOR = 1.69 (95%CI 1.52-1.87)]. One unit increase of NLR is equal to 30% and 44% increased risk of ISR in coronary and non-coronary patients. Included studies showing NLR as a robust predictor of ISR with sensitivity and specificity of 70.5% (95%CI 60.1%-79.2%) and 74.1% (95%CI 56.7%-86.2%) for coronary stenting and 77.7% (95%CI 69.8%-84.0%) and 66.4% (95%CI 49.6%-79.8%) non-coronary stenting, with AUC of 0.77 (0.70-0.82) in the coronary and 0.79 (0.70-0.85) in the non-coronary sub-groups.<h4>Conclusion</h4>In conclusion, NLR yields promising predictive and prognostic potentials in predicting ISR in coronary and non-coronary stents. Additionally, NLR appears to be more proficient in predicting early ISR compared to late ISR in both coronary and non-coronary stents.https://doi.org/10.1371/journal.pone.0322461 |
| spellingShingle | Paulus Parholong Siahaan Wynne Widiarti Pandit Bagus Tri Saputra Rendra Mahardhika Putra Mario D'Oria Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. PLoS ONE |
| title | Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. |
| title_full | Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. |
| title_fullStr | Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. |
| title_short | Neutrophil-to-lymphocyte ratio as a potential biomarker in predicting in-stent restenosis: A systematic review and meta-analysis. |
| title_sort | neutrophil to lymphocyte ratio as a potential biomarker in predicting in stent restenosis a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0322461 |
| work_keys_str_mv | AT paulusparholongsiahaan neutrophiltolymphocyteratioasapotentialbiomarkerinpredictinginstentrestenosisasystematicreviewandmetaanalysis AT wynnewidiarti neutrophiltolymphocyteratioasapotentialbiomarkerinpredictinginstentrestenosisasystematicreviewandmetaanalysis AT panditbagustrisaputra neutrophiltolymphocyteratioasapotentialbiomarkerinpredictinginstentrestenosisasystematicreviewandmetaanalysis AT rendramahardhikaputra neutrophiltolymphocyteratioasapotentialbiomarkerinpredictinginstentrestenosisasystematicreviewandmetaanalysis AT mariodoria neutrophiltolymphocyteratioasapotentialbiomarkerinpredictinginstentrestenosisasystematicreviewandmetaanalysis |