Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice
Abstract To explore the effects of methionine (Met) supplementation on cognitive dysfunction and the associated mechanisms in aging mice. The mice were administrated 0.15 g/kg/day D-galactose subcutaneously and fed a normal (0.86% Met) or a Met-supplemented diet (1.72% Met) for 11 weeks. Behavioral...
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Nature Portfolio
2024-12-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-024-00348-w |
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| author | Yuncong Xu Yuhui Yang Yonghui Shi Bowen Li Yanli Xie Guowei Le |
| author_facet | Yuncong Xu Yuhui Yang Yonghui Shi Bowen Li Yanli Xie Guowei Le |
| author_sort | Yuncong Xu |
| collection | DOAJ |
| description | Abstract To explore the effects of methionine (Met) supplementation on cognitive dysfunction and the associated mechanisms in aging mice. The mice were administrated 0.15 g/kg/day D-galactose subcutaneously and fed a normal (0.86% Met) or a Met-supplemented diet (1.72% Met) for 11 weeks. Behavioral experiments were conducted, and we measured the plasma metabolite levels, hippocampal and plasma redox and inflammatory states, and hippocampal transsulfuration pathway-related parameters. Met supplementation prevented aging-induced anxiety and cognitive deficiencies, and normalized the plasma levels of multiple systemic metabolites (e.g., betaine, taurine, and choline). Furthermore, dietary Met supplementation abolished oxidative stress and inflammation, selectively modulated the expression of multiple cognition-related genes and proteins, and increased flux via the transsulfuration pathway in the hippocampi of aging mice, with significant increase in H2S and glutathione production. Our findings suggest that dietary Met supplementation prevented cognitive deficiencies in aging mice, probably because of increased flux via the transsulfuration pathway. |
| format | Article |
| id | doaj-art-ea1801c6cde34964a2f3ed469aa63a51 |
| institution | OA Journals |
| issn | 2396-8370 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-ea1801c6cde34964a2f3ed469aa63a512025-08-20T02:32:26ZengNature Portfolionpj Science of Food2396-83702024-12-018111610.1038/s41538-024-00348-wDietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging miceYuncong Xu0Yuhui Yang1Yonghui Shi2Bowen Li3Yanli Xie4Guowei Le5Henan Key Laboratory of cereal and Oil Food Safety Inspection and Control, College of Food Science and Engineering, Henan University of TechnologyHenan Key Laboratory of cereal and Oil Food Safety Inspection and Control, College of Food Science and Engineering, Henan University of TechnologyState Key Laboratory of Food Science and Resources, Jiangnan UniversityState Key Laboratory of Food Science and Resources, Jiangnan UniversityHenan Key Laboratory of cereal and Oil Food Safety Inspection and Control, College of Food Science and Engineering, Henan University of TechnologyState Key Laboratory of Food Science and Resources, Jiangnan UniversityAbstract To explore the effects of methionine (Met) supplementation on cognitive dysfunction and the associated mechanisms in aging mice. The mice were administrated 0.15 g/kg/day D-galactose subcutaneously and fed a normal (0.86% Met) or a Met-supplemented diet (1.72% Met) for 11 weeks. Behavioral experiments were conducted, and we measured the plasma metabolite levels, hippocampal and plasma redox and inflammatory states, and hippocampal transsulfuration pathway-related parameters. Met supplementation prevented aging-induced anxiety and cognitive deficiencies, and normalized the plasma levels of multiple systemic metabolites (e.g., betaine, taurine, and choline). Furthermore, dietary Met supplementation abolished oxidative stress and inflammation, selectively modulated the expression of multiple cognition-related genes and proteins, and increased flux via the transsulfuration pathway in the hippocampi of aging mice, with significant increase in H2S and glutathione production. Our findings suggest that dietary Met supplementation prevented cognitive deficiencies in aging mice, probably because of increased flux via the transsulfuration pathway.https://doi.org/10.1038/s41538-024-00348-w |
| spellingShingle | Yuncong Xu Yuhui Yang Yonghui Shi Bowen Li Yanli Xie Guowei Le Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice npj Science of Food |
| title | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| title_full | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| title_fullStr | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| title_full_unstemmed | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| title_short | Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| title_sort | dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in subacute aging mice |
| url | https://doi.org/10.1038/s41538-024-00348-w |
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