Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
T3 (3,5,3′-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases. The present study was designed to evaluate the cardioprotective action of T3 in isoproterenol-(ISO-) induced cardiac toxicity. Female Wistar rats were exposed with ISO (100 mg/kg, body we...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/908367 |
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| author | Vinay Mishra Priya Ghumatkar Maulik V. Patel Shilpesh Devada Ramchandra Ranvir Prabodha Swain Rajesh Sundar Rajesh Bahekar Mukul R. Jain |
| author_facet | Vinay Mishra Priya Ghumatkar Maulik V. Patel Shilpesh Devada Ramchandra Ranvir Prabodha Swain Rajesh Sundar Rajesh Bahekar Mukul R. Jain |
| author_sort | Vinay Mishra |
| collection | DOAJ |
| description | T3 (3,5,3′-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases. The present study was designed to evaluate the cardioprotective action of T3 in isoproterenol-(ISO-) induced cardiac toxicity. Female Wistar rats were exposed with ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 h followed by T3 (3 μg/kg, body weight, orally) treatment for 3 days. Positive control rats received only ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 hrs. Control group animals received normal saline as a vehicle. As expected, ISO-induced significant changes were observed in low-density lipoprotein, total cholesterol, ALT, CK-MB to TCK ratio, and prolongation of QT interval in electrocardiogram, which is toward normalization after T3 treatment. Lower heart weight, upregulation of cardiac myosin heavy chain alpha (MHC-α), and reduced inflammatory cell infiltration, myonecrosis, vacuolar changes, and a trend toward normal cardiac muscle fiber architecture in microscopic examination of cardiac tissue further support the cardioprotective effect of T3. |
| format | Article |
| id | doaj-art-ea146db8a2f14d6cbc93649d53749145 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ea146db8a2f14d6cbc93649d537491452025-02-03T00:59:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/908367908367Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced CardiotoxicityVinay Mishra0Priya Ghumatkar1Maulik V. Patel2Shilpesh Devada3Ramchandra Ranvir4Prabodha Swain5Rajesh Sundar6Rajesh Bahekar7Mukul R. Jain8Department of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Molecular Pharmacology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Medicinal Chemistry, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaDepartment of Pharmacology and Toxicology, Zydus Research Center, Sarkhej-Bavla N.H. No. 8A, Moraiya, Ahmedabad 382213, IndiaT3 (3,5,3′-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases. The present study was designed to evaluate the cardioprotective action of T3 in isoproterenol-(ISO-) induced cardiac toxicity. Female Wistar rats were exposed with ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 h followed by T3 (3 μg/kg, body weight, orally) treatment for 3 days. Positive control rats received only ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 hrs. Control group animals received normal saline as a vehicle. As expected, ISO-induced significant changes were observed in low-density lipoprotein, total cholesterol, ALT, CK-MB to TCK ratio, and prolongation of QT interval in electrocardiogram, which is toward normalization after T3 treatment. Lower heart weight, upregulation of cardiac myosin heavy chain alpha (MHC-α), and reduced inflammatory cell infiltration, myonecrosis, vacuolar changes, and a trend toward normal cardiac muscle fiber architecture in microscopic examination of cardiac tissue further support the cardioprotective effect of T3.http://dx.doi.org/10.1155/2011/908367 |
| spellingShingle | Vinay Mishra Priya Ghumatkar Maulik V. Patel Shilpesh Devada Ramchandra Ranvir Prabodha Swain Rajesh Sundar Rajesh Bahekar Mukul R. Jain Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity International Journal of Endocrinology |
| title | Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity |
| title_full | Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity |
| title_fullStr | Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity |
| title_full_unstemmed | Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity |
| title_short | Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity |
| title_sort | evaluation of cardioprotective effect of 3 5 3 tri iodo l thyronine in isoproterenol induced cardiotoxicity |
| url | http://dx.doi.org/10.1155/2011/908367 |
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