Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats
Background: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pr...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629350410001664806 |
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| author | Aluet Borrego Zullyt B. Zamora Ricardo González Cheyla Romay Silvia Menéndez Frank Hernández Teresita Montero Enys Rojas |
| author_facet | Aluet Borrego Zullyt B. Zamora Ricardo González Cheyla Romay Silvia Menéndez Frank Hernández Teresita Montero Enys Rojas |
| author_sort | Aluet Borrego |
| collection | DOAJ |
| description | Background: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pro-oxidant balance for preservation of the cell redox state by increasing antioxidant endogenous systems in various in vivo and in vitro experimental models. |
| format | Article |
| id | doaj-art-ea143ab70ec441cd86e2b8d012254fc3 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ea143ab70ec441cd86e2b8d012254fc32025-08-20T02:21:46ZengWileyMediators of Inflammation0962-93511466-18612004-01-01131131910.1080/09629350410001664806Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in ratsAluet Borrego0Zullyt B. Zamora1Ricardo González2Cheyla Romay3Silvia Menéndez4Frank Hernández5Teresita Montero6Enys Rojas7Department of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, Cuba'Dr. Luis Díaz Sot#39; Surgical and Clinical Hospital, Havana, CubaDepartment of Biomedicine, Ozone Research Center, National Center for Scientific Research, Biomedicine Department, P.O. Box 6414, Havana, CubaBackground: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pro-oxidant balance for preservation of the cell redox state by increasing antioxidant endogenous systems in various in vivo and in vitro experimental models.http://dx.doi.org/10.1080/09629350410001664806Ozone oxidative preconditioningCisplatin-induced nephrotoxicityAntioxidant defensesLipid peroxidation. |
| spellingShingle | Aluet Borrego Zullyt B. Zamora Ricardo González Cheyla Romay Silvia Menéndez Frank Hernández Teresita Montero Enys Rojas Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats Mediators of Inflammation Ozone oxidative preconditioning Cisplatin-induced nephrotoxicity Antioxidant defenses Lipid peroxidation. |
| title | Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats |
| title_full | Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats |
| title_fullStr | Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats |
| title_full_unstemmed | Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats |
| title_short | Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats |
| title_sort | protection by ozone preconditioning is mediated by the antioxidant system in cisplatin induced nephrotoxicity in rats |
| topic | Ozone oxidative preconditioning Cisplatin-induced nephrotoxicity Antioxidant defenses Lipid peroxidation. |
| url | http://dx.doi.org/10.1080/09629350410001664806 |
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