Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury
ObjectiveTo explore the efficacies of continuous renal replacement （CRRT） versus intermittent hemodialysis （IHD） for urinary insulin-like growth factor binding protein 7 （IGFBP-7） and tissue inhibitor of metalloproteinase-2 （TIMP-2） and compare the differences in blood levels of neutrophil gelatinas...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-02-01
|
| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.02.002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186893329694720 |
|---|---|
| author | Wang Xiang Zhang Zhi-min Li Jian-guo Song Ya-jun |
| author_facet | Wang Xiang Zhang Zhi-min Li Jian-guo Song Ya-jun |
| author_sort | Wang Xiang |
| collection | DOAJ |
| description | ObjectiveTo explore the efficacies of continuous renal replacement （CRRT） versus intermittent hemodialysis （IHD） for urinary insulin-like growth factor binding protein 7 （IGFBP-7） and tissue inhibitor of metalloproteinase-2 （TIMP-2） and compare the differences in blood levels of neutrophil gelatinase-associated lipocalin （NGAL）in septic patients with acute kidney injury （AKI）.MethodsFrom January to September 2019，100 hospitalized septic patients with AKI were divided into two groups of observation and control according to specific treatment mode （<italic>n</italic>=50 each）. Observation group underwent CRRT while control group had IHD. All cardiac function tests were completed and blood biochemical parameters detected during treatment. The inter-group differences of urinary levels of IGFBP-7，TIMP-2 and NGAL were analyzed. For comparing two groups pre/post-treatment，mean arterial pressure （MAP），left ventricular ejection fraction （LVEF），cardiac index （CI），cardiac output （CO），inflammatory factor parameters of C-reactive protein （CRP），white blood count （WBC），procalcitonin （PCT），renal function parameters of blood urea nitrogen （BUN） and serum creatinine （Scr） and differences of APACHE Ⅱwere recorded.ResultsThe recovery time of urinary volume，organ support time，intensive care unit （ICU） stay and incidence rate of cardiovascular events were significantly lower in observation group than those in control group. And the differences had statistical significance （<italic>P</italic><0.05）. After treatment，LVEF，CI and CO were significantly higher in observation group than those in control group and the differences had statistical significance（<italic>P</italic><0.05）. CRP，WBC，PCT，BUN，Scr and APACHE II were significantly lower in both groups than thosepre-treatment. And observation group was significantly lower than control group and the differences were statistically significant （<italic>P</italic><0.05）. The urinary levels of IGFBP-7，TIMP-2 and NGAL were significantly lower in observation group post-treatment than those pre-treatment. All were significantly lower than those in control group and the differences had statistical significance （<italic>P</italic><0.05）.ConclusionsMore effective than IHD in the treatment of sepsis with AKI，CRRT can effectively shorten ICU stay and improve the urinary levels of IGFBP-7，TIMP-2 and NGAL. It is worthy of wider clinical applications. |
| format | Article |
| id | doaj-art-ea1263258e864dd9a1ad35461ce46bd4 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-02-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-ea1263258e864dd9a1ad35461ce46bd42025-08-20T02:16:14ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-02-0122949923501820Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injuryWang XiangZhang Zhi-minLi Jian-guoSong Ya-junObjectiveTo explore the efficacies of continuous renal replacement （CRRT） versus intermittent hemodialysis （IHD） for urinary insulin-like growth factor binding protein 7 （IGFBP-7） and tissue inhibitor of metalloproteinase-2 （TIMP-2） and compare the differences in blood levels of neutrophil gelatinase-associated lipocalin （NGAL）in septic patients with acute kidney injury （AKI）.MethodsFrom January to September 2019，100 hospitalized septic patients with AKI were divided into two groups of observation and control according to specific treatment mode （<italic>n</italic>=50 each）. Observation group underwent CRRT while control group had IHD. All cardiac function tests were completed and blood biochemical parameters detected during treatment. The inter-group differences of urinary levels of IGFBP-7，TIMP-2 and NGAL were analyzed. For comparing two groups pre/post-treatment，mean arterial pressure （MAP），left ventricular ejection fraction （LVEF），cardiac index （CI），cardiac output （CO），inflammatory factor parameters of C-reactive protein （CRP），white blood count （WBC），procalcitonin （PCT），renal function parameters of blood urea nitrogen （BUN） and serum creatinine （Scr） and differences of APACHE Ⅱwere recorded.ResultsThe recovery time of urinary volume，organ support time，intensive care unit （ICU） stay and incidence rate of cardiovascular events were significantly lower in observation group than those in control group. And the differences had statistical significance （<italic>P</italic><0.05）. After treatment，LVEF，CI and CO were significantly higher in observation group than those in control group and the differences had statistical significance（<italic>P</italic><0.05）. CRP，WBC，PCT，BUN，Scr and APACHE II were significantly lower in both groups than thosepre-treatment. And observation group was significantly lower than control group and the differences were statistically significant （<italic>P</italic><0.05）. The urinary levels of IGFBP-7，TIMP-2 and NGAL were significantly lower in observation group post-treatment than those pre-treatment. All were significantly lower than those in control group and the differences had statistical significance （<italic>P</italic><0.05）.ConclusionsMore effective than IHD in the treatment of sepsis with AKI，CRRT can effectively shorten ICU stay and improve the urinary levels of IGFBP-7，TIMP-2 and NGAL. It is worthy of wider clinical applications.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.02.002Continuous renal replacement therapyIntermittent hemodialysisSepsisAcute kidney injury |
| spellingShingle | Wang Xiang Zhang Zhi-min Li Jian-guo Song Ya-jun Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury Linchuang shenzangbing zazhi Continuous renal replacement therapy Intermittent hemodialysis Sepsis Acute kidney injury |
| title | Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury |
| title_full | Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury |
| title_fullStr | Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury |
| title_full_unstemmed | Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury |
| title_short | Differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin-like growth factor binding protein 7，neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinase-2 in septic patients complicated with acute kidney injury |
| title_sort | differences in efficacies of continuous renal replacement therapy and intermittent hemodialysis upon urinary levels of insulin like growth factor binding protein 7 neutrophil gelatinase associated lipocalin and tissue inhibitor of metalloproteinase 2 in septic patients complicated with acute kidney injury |
| topic | Continuous renal replacement therapy Intermittent hemodialysis Sepsis Acute kidney injury |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.02.002 |
| work_keys_str_mv | AT wangxiang differencesinefficaciesofcontinuousrenalreplacementtherapyandintermittenthemodialysisuponurinarylevelsofinsulinlikegrowthfactorbindingprotein7neutrophilgelatinaseassociatedlipocalinandtissueinhibitorofmetalloproteinase2insepticpatientscomplicatedwithacute AT zhangzhimin differencesinefficaciesofcontinuousrenalreplacementtherapyandintermittenthemodialysisuponurinarylevelsofinsulinlikegrowthfactorbindingprotein7neutrophilgelatinaseassociatedlipocalinandtissueinhibitorofmetalloproteinase2insepticpatientscomplicatedwithacute AT lijianguo differencesinefficaciesofcontinuousrenalreplacementtherapyandintermittenthemodialysisuponurinarylevelsofinsulinlikegrowthfactorbindingprotein7neutrophilgelatinaseassociatedlipocalinandtissueinhibitorofmetalloproteinase2insepticpatientscomplicatedwithacute AT songyajun differencesinefficaciesofcontinuousrenalreplacementtherapyandintermittenthemodialysisuponurinarylevelsofinsulinlikegrowthfactorbindingprotein7neutrophilgelatinaseassociatedlipocalinandtissueinhibitorofmetalloproteinase2insepticpatientscomplicatedwithacute |