Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus
Objective: To examine the associations between three adipokines (omentin-1, nesfatin-1 and apelin) and diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM), so as to provide the basis for the prevention and control of DR. Methods: The T2DM patients hospitalized in Lishui TCM...
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Editorial Office of China Preventive Medicine Journal
2025-03-01
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| Series: | 预防医学 |
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| Online Access: | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.03.007 |
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| author | SUN Xia, DAN lingying, ZHENG Peng, CHEN Xinyi |
| author_facet | SUN Xia, DAN lingying, ZHENG Peng, CHEN Xinyi |
| author_sort | SUN Xia, DAN lingying, ZHENG Peng, CHEN Xinyi |
| collection | DOAJ |
| description | Objective: To examine the associations between three adipokines (omentin-1, nesfatin-1 and apelin) and diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM), so as to provide the basis for the prevention and control of DR. Methods: The T2DM patients hospitalized in Lishui TCM Hospital from August 2021 to May 2023 were selected and divided into three groups: no diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group based on fundus fluorescein angiography. Data on gender, age, and course of T2DM were collected through questionnaires, and serum omentin-1, nesfatin-1, apelin, and related blood biochemical indicators were measured. The associations of omentin-1, nesfatin-1 and apelin with DR were analyzed using a multinomial logistic regression model. Results: A total of 150 T2DM patients were enrolled, including 58 cases in the NDR group, 60 cases in the NPDR group, and 32 cases in the PDR group, with males accounting for 60.34%, 45.00% and 68.75%, respectively. The mean ages were (54.79±14.40), (57.03±12.20) and (57.72±10.70) years, respectively. The median (interquartile range) courses of T2DM were 7.00 (7.75), 10.00 (8.00) and 10.00 (5.00) years, respectively. Compared with the NDR group, the NPDR group had lower levels of omentin-1 and nesfatin-1 and higher level of apelin, while the PDR group had higher level of omentin-1 and lower level of apelin (all P<0.05). Compared with the NPDR group, the PDR group had higher levels of omentin-1 and nesfatin-1 and lower level of apelin (all P<0.05). Multinomial logistic regression analysis showed that omentin-1 level was statistically associated with NPDR (OR=0.503, 95%CI: 0.291-0.871) and PDR (OR=7.862, 95%CI: 2.956-20.910); nesfatin-1 (OR=0.971, 95%CI: 0.953-0.989) and apelin (OR=3.266, 95%CI: 1.817-5.868) levels were statistically associated with NPDR. Conclusion: Serum levels of omentin-1, nesfatin-1 and apelin were associated with different stages of DR among T2DM patients. |
| format | Article |
| id | doaj-art-ea115be91bf74ccbb55b9bfa7e685ce0 |
| institution | OA Journals |
| issn | 2096-5087 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of China Preventive Medicine Journal |
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| series | 预防医学 |
| spelling | doaj-art-ea115be91bf74ccbb55b9bfa7e685ce02025-08-20T02:09:26ZzhoEditorial Office of China Preventive Medicine Journal预防医学2096-50872025-03-0137324825210.19485/j.cnki.issn2096-5087.2025.03.007Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitusSUN Xia, DAN lingying, ZHENG Peng, CHEN XinyiObjective: To examine the associations between three adipokines (omentin-1, nesfatin-1 and apelin) and diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM), so as to provide the basis for the prevention and control of DR. Methods: The T2DM patients hospitalized in Lishui TCM Hospital from August 2021 to May 2023 were selected and divided into three groups: no diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group based on fundus fluorescein angiography. Data on gender, age, and course of T2DM were collected through questionnaires, and serum omentin-1, nesfatin-1, apelin, and related blood biochemical indicators were measured. The associations of omentin-1, nesfatin-1 and apelin with DR were analyzed using a multinomial logistic regression model. Results: A total of 150 T2DM patients were enrolled, including 58 cases in the NDR group, 60 cases in the NPDR group, and 32 cases in the PDR group, with males accounting for 60.34%, 45.00% and 68.75%, respectively. The mean ages were (54.79±14.40), (57.03±12.20) and (57.72±10.70) years, respectively. The median (interquartile range) courses of T2DM were 7.00 (7.75), 10.00 (8.00) and 10.00 (5.00) years, respectively. Compared with the NDR group, the NPDR group had lower levels of omentin-1 and nesfatin-1 and higher level of apelin, while the PDR group had higher level of omentin-1 and lower level of apelin (all P<0.05). Compared with the NPDR group, the PDR group had higher levels of omentin-1 and nesfatin-1 and lower level of apelin (all P<0.05). Multinomial logistic regression analysis showed that omentin-1 level was statistically associated with NPDR (OR=0.503, 95%CI: 0.291-0.871) and PDR (OR=7.862, 95%CI: 2.956-20.910); nesfatin-1 (OR=0.971, 95%CI: 0.953-0.989) and apelin (OR=3.266, 95%CI: 1.817-5.868) levels were statistically associated with NPDR. Conclusion: Serum levels of omentin-1, nesfatin-1 and apelin were associated with different stages of DR among T2DM patients.http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.03.007diabetic retinopathytype 2 diabetes mellitusomentin-1nesfatin-1apelin |
| spellingShingle | SUN Xia, DAN lingying, ZHENG Peng, CHEN Xinyi Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus 预防医学 diabetic retinopathy type 2 diabetes mellitus omentin-1 nesfatin-1 apelin |
| title | Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| title_full | Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| title_fullStr | Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| title_full_unstemmed | Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| title_short | Associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| title_sort | associations of adipokine with diabetic retinopathy among patients with type 2 diabetes mellitus |
| topic | diabetic retinopathy type 2 diabetes mellitus omentin-1 nesfatin-1 apelin |
| url | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.03.007 |
| work_keys_str_mv | AT sunxiadanlingyingzhengpengchenxinyi associationsofadipokinewithdiabeticretinopathyamongpatientswithtype2diabetesmellitus |