In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration
Bone tissue regeneration is a major, worldwide medical need, and several strategies have been developed to support the regeneration of extensive bone defects, including stem cell based bone grafts. In addition to the application of stem cells with high osteogenic potential, it is important to mainta...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/3595941 |
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| _version_ | 1849434585202425856 |
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| author | Áron Szepesi Zsolt Matula Anna Szigeti György Várady József Szalma Gyula Szabó Ferenc Uher Balázs Sarkadi Katalin Német |
| author_facet | Áron Szepesi Zsolt Matula Anna Szigeti György Várady József Szalma Gyula Szabó Ferenc Uher Balázs Sarkadi Katalin Német |
| author_sort | Áron Szepesi |
| collection | DOAJ |
| description | Bone tissue regeneration is a major, worldwide medical need, and several strategies have been developed to support the regeneration of extensive bone defects, including stem cell based bone grafts. In addition to the application of stem cells with high osteogenic potential, it is important to maintain proper blood flow in a bone graft to avoid inner graft necrosis. Mesenchymal stem cells (MSCs) may form both osteocytes and endothelial cells; therefore we examined the combined in vitro osteogenic and endothelial differentiation capacities of MSCs derived from adipose tissue, Wharton’s jelly, and periodontal ligament. Based on a detailed characterization presented here, MSCs isolated from adipose tissue and periodontal ligament may be most appropriate for generating vascularized bone grafts. |
| format | Article |
| id | doaj-art-ea0c32c92a944ee5b8d1c50f0648969c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ea0c32c92a944ee5b8d1c50f0648969c2025-08-20T03:26:35ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/35959413595941In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone RegenerationÁron Szepesi0Zsolt Matula1Anna Szigeti2György Várady3József Szalma4Gyula Szabó5Ferenc Uher6Balázs Sarkadi7Katalin Német8Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HungaryResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HungaryResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HungaryResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HungaryDepartment of Dentistry, Oral and Maxillofacial Surgery, University of Pécs Medical School, Pécs, HungaryDepartment of Dentistry, Oral and Maxillofacial Surgery, University of Pécs Medical School, Pécs, HungaryNational Blood Service, Budapest, HungaryResearch Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HungaryCreative Cell Ltd., Budapest, HungaryBone tissue regeneration is a major, worldwide medical need, and several strategies have been developed to support the regeneration of extensive bone defects, including stem cell based bone grafts. In addition to the application of stem cells with high osteogenic potential, it is important to maintain proper blood flow in a bone graft to avoid inner graft necrosis. Mesenchymal stem cells (MSCs) may form both osteocytes and endothelial cells; therefore we examined the combined in vitro osteogenic and endothelial differentiation capacities of MSCs derived from adipose tissue, Wharton’s jelly, and periodontal ligament. Based on a detailed characterization presented here, MSCs isolated from adipose tissue and periodontal ligament may be most appropriate for generating vascularized bone grafts.http://dx.doi.org/10.1155/2016/3595941 |
| spellingShingle | Áron Szepesi Zsolt Matula Anna Szigeti György Várady József Szalma Gyula Szabó Ferenc Uher Balázs Sarkadi Katalin Német In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration Stem Cells International |
| title | In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration |
| title_full | In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration |
| title_fullStr | In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration |
| title_full_unstemmed | In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration |
| title_short | In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration |
| title_sort | in vitro characterization of human mesenchymal stem cells isolated from different tissues with a potential to promote complex bone regeneration |
| url | http://dx.doi.org/10.1155/2016/3595941 |
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