Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management
MI is a leading cause of morbidity and mortality worldwide. Coronary artery thrombosis is the final pathologic feature of the most cases of acute MI primarily caused by atherosclerotic coronary artery disease. The concept of vulnerable plaque has evolved over the years but originated from early pion...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2022-01-01
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| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articleindex/usc.2021.22 |
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| _version_ | 1850104673452687360 |
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| author | Atsushi Sakamoto Anne Cornelissen Yu Sato Masayuki Mori Rika Kawakami Kenji Kawai Saikat Kumar B Ghosh Weili Xu Biniyam G Abebe Armelle Dikongue Frank D Kolodgie Renu Virmani Aloke V Finn |
| author_facet | Atsushi Sakamoto Anne Cornelissen Yu Sato Masayuki Mori Rika Kawakami Kenji Kawai Saikat Kumar B Ghosh Weili Xu Biniyam G Abebe Armelle Dikongue Frank D Kolodgie Renu Virmani Aloke V Finn |
| author_sort | Atsushi Sakamoto |
| collection | DOAJ |
| description | MI is a leading cause of morbidity and mortality worldwide. Coronary artery thrombosis is the final pathologic feature of the most cases of acute MI primarily caused by atherosclerotic coronary artery disease. The concept of vulnerable plaque has evolved over the years but originated from early pioneering work unveiling the crucial role of plaque rupture and subsequent coronary thrombosis as the dominant cause of MI. Along with systemic cardiovascular risk factors, developments of intravascular and non-invasive imaging modalities have allowed us to identify coronary plaques thought to be at high risk for rupture. However, morphological features alone may only be one of many factors which promote plaque progression. The current vulnerable-plaque-oriented approaches to accomplish personalized risk assessment and treatment have significant room for improvement. In this review, the authors discuss recent advances in the understanding of vulnerable plaque and its management strategy from pathology and clinical perspectives. |
| format | Article |
| id | doaj-art-ea0b6ab68bf44e56962b2242c61e5a9c |
| institution | DOAJ |
| issn | 1758-3896 1758-390X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj-art-ea0b6ab68bf44e56962b2242c61e5a9c2025-08-20T02:39:16ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2022-01-011610.15420/usc.2021.22Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and ManagementAtsushi SakamotoAnne CornelissenYu SatoMasayuki MoriRika KawakamiKenji KawaiSaikat Kumar B GhoshWeili XuBiniyam G AbebeArmelle DikongueFrank D KolodgieRenu VirmaniAloke V FinnMI is a leading cause of morbidity and mortality worldwide. Coronary artery thrombosis is the final pathologic feature of the most cases of acute MI primarily caused by atherosclerotic coronary artery disease. The concept of vulnerable plaque has evolved over the years but originated from early pioneering work unveiling the crucial role of plaque rupture and subsequent coronary thrombosis as the dominant cause of MI. Along with systemic cardiovascular risk factors, developments of intravascular and non-invasive imaging modalities have allowed us to identify coronary plaques thought to be at high risk for rupture. However, morphological features alone may only be one of many factors which promote plaque progression. The current vulnerable-plaque-oriented approaches to accomplish personalized risk assessment and treatment have significant room for improvement. In this review, the authors discuss recent advances in the understanding of vulnerable plaque and its management strategy from pathology and clinical perspectives.https://www.uscjournal.com/articleindex/usc.2021.22 |
| spellingShingle | Atsushi Sakamoto Anne Cornelissen Yu Sato Masayuki Mori Rika Kawakami Kenji Kawai Saikat Kumar B Ghosh Weili Xu Biniyam G Abebe Armelle Dikongue Frank D Kolodgie Renu Virmani Aloke V Finn Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management US Cardiology Review |
| title | Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management |
| title_full | Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management |
| title_fullStr | Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management |
| title_full_unstemmed | Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management |
| title_short | Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management |
| title_sort | vulnerable plaque in patients with acute coronary syndrome identification importance and management |
| url | https://www.uscjournal.com/articleindex/usc.2021.22 |
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