Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study
ABSTRACT Objective To compare the effects of two different protocols, ketamine with dexmedetomidine (ketamine‐dexmedetomidine [KD]) and ketamine with propofol (ketamine‐propofol [KP]), on intubation time, selected cardiopulmonary parameters, and anaesthesia maintenance during canine orchiectomy in a...
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Wiley
2025-05-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.70412 |
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| author | Mumin Gokhan Senocak |
| author_facet | Mumin Gokhan Senocak |
| author_sort | Mumin Gokhan Senocak |
| collection | DOAJ |
| description | ABSTRACT Objective To compare the effects of two different protocols, ketamine with dexmedetomidine (ketamine‐dexmedetomidine [KD]) and ketamine with propofol (ketamine‐propofol [KP]), on intubation time, selected cardiopulmonary parameters, and anaesthesia maintenance during canine orchiectomy in a clinical setting. Study Design Randomized clinical trial. Animals Twenty‐six healthy dogs were undergoing orchiectomy. Methods Dogs were randomly assigned to the KD group [n = 13; single intravenous bolus of ketamine (5 mg kg−1) combined with dexmedetomidine (10 µg kg−1)], or KP group [n = 13, an intravenous bolus of ketamine combined with propofol at a 1:2 concentration ratio and infused at a 0.2 mL kg−1 min−1 rate for 120 s until jaw relaxation and the consumed amount recorded]. Orotracheal intubation followed the induction of anaesthesia. The cardiopulmonary variables were assessed at baseline and 5‐min intervals up to 30 min. A 20% increase in at least two variables, such as heart rate (HR), mean arterial pressure (MAP) and respiratory rate, prompted the administration of top‐ups. Following surgery, the recovery time and quality were assessed. Results There was no significant difference in intubation time between KD (3.3 ± 0.8) and KP (2.7 ± 0.9, p = 0.121). Over time, HR and MAP significantly increased in the KP group compared to the KD group (p < 0.001). The haemoglobin oxygen saturation was higher in the KD group (97.7% ± 2.1%) compared to the KP (95.3% ± 2.2%, p = 0.015). The duration of the top‐up requirement was longer in the KD group as compared to a single bolus of KP, with a mean difference of 31.2 min (95% CI 20.80–41.51) (p < 0.01). Conclusions and Clinical Relevance Both KP and KD combinations effectively maintain anaesthesia during canine castration surgery, demonstrating comparable intubation times. Although KP requires additional top‐ups, it potentially offers enhanced cardiovascular stability compared to KD. However, the use of KP necessitates support of body temperature and oxygenation. |
| format | Article |
| id | doaj-art-ea0a5f35ca2946b1881c08cc0b8c1413 |
| institution | OA Journals |
| issn | 2053-1095 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Veterinary Medicine and Science |
| spelling | doaj-art-ea0a5f35ca2946b1881c08cc0b8c14132025-08-20T02:30:12ZengWileyVeterinary Medicine and Science2053-10952025-05-01113n/an/a10.1002/vms3.70412Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized StudyMumin Gokhan Senocak0Department of Surgery, Faculty of Veterinary Medicine Atatürk University Erzurum TurkeyABSTRACT Objective To compare the effects of two different protocols, ketamine with dexmedetomidine (ketamine‐dexmedetomidine [KD]) and ketamine with propofol (ketamine‐propofol [KP]), on intubation time, selected cardiopulmonary parameters, and anaesthesia maintenance during canine orchiectomy in a clinical setting. Study Design Randomized clinical trial. Animals Twenty‐six healthy dogs were undergoing orchiectomy. Methods Dogs were randomly assigned to the KD group [n = 13; single intravenous bolus of ketamine (5 mg kg−1) combined with dexmedetomidine (10 µg kg−1)], or KP group [n = 13, an intravenous bolus of ketamine combined with propofol at a 1:2 concentration ratio and infused at a 0.2 mL kg−1 min−1 rate for 120 s until jaw relaxation and the consumed amount recorded]. Orotracheal intubation followed the induction of anaesthesia. The cardiopulmonary variables were assessed at baseline and 5‐min intervals up to 30 min. A 20% increase in at least two variables, such as heart rate (HR), mean arterial pressure (MAP) and respiratory rate, prompted the administration of top‐ups. Following surgery, the recovery time and quality were assessed. Results There was no significant difference in intubation time between KD (3.3 ± 0.8) and KP (2.7 ± 0.9, p = 0.121). Over time, HR and MAP significantly increased in the KP group compared to the KD group (p < 0.001). The haemoglobin oxygen saturation was higher in the KD group (97.7% ± 2.1%) compared to the KP (95.3% ± 2.2%, p = 0.015). The duration of the top‐up requirement was longer in the KD group as compared to a single bolus of KP, with a mean difference of 31.2 min (95% CI 20.80–41.51) (p < 0.01). Conclusions and Clinical Relevance Both KP and KD combinations effectively maintain anaesthesia during canine castration surgery, demonstrating comparable intubation times. Although KP requires additional top‐ups, it potentially offers enhanced cardiovascular stability compared to KD. However, the use of KP necessitates support of body temperature and oxygenation.https://doi.org/10.1002/vms3.70412canine castrationdexmedetomidineketamineketadexketofolpropofol |
| spellingShingle | Mumin Gokhan Senocak Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study Veterinary Medicine and Science canine castration dexmedetomidine ketamine ketadex ketofol propofol |
| title | Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study |
| title_full | Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study |
| title_fullStr | Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study |
| title_full_unstemmed | Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study |
| title_short | Clinical Comparison of Ketamine‐Dexmedetomidine With Ketamine‐Propofol During Canine Orchiectomy: A Randomized Study |
| title_sort | clinical comparison of ketamine dexmedetomidine with ketamine propofol during canine orchiectomy a randomized study |
| topic | canine castration dexmedetomidine ketamine ketadex ketofol propofol |
| url | https://doi.org/10.1002/vms3.70412 |
| work_keys_str_mv | AT mumingokhansenocak clinicalcomparisonofketaminedexmedetomidinewithketaminepropofolduringcanineorchiectomyarandomizedstudy |