Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer

Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer

IntroductionEpidermal growth factor receptor 2 (HER2) and programmed cell death ligand 1 (PD-L1) are pivotal therapeutic targets for advanced gastric cancer (GC). Nevertheless, the correlation between them, along with the clinical and genomic characteristics and prognosis differences across distinct...

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Main Authors: Jun Yao, Qiang Sun, Han Wu, Xiaokai Zhao, Pengmin Yang, Xiaozhi Wang, Xintao Wang, Meiping Gu, Jieyi Li, Yuansi Zheng, Ziying Gong, Daoyun Zhang, Weijun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
HER2 amplification
TP53 mutation
PD-L1 CPS strata
advanced gastric cancer
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567308/full
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