Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial
Background. Oxidative processes might increase in patients with end-stage renal disease (ESRD) according to the current literature. Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. Haemodialysis (HD)...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/7214673 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550177253097472 |
|---|---|
| author | Nour Elkhair Ali Lamis AbdelGadir Kaddam Suad Yousif Alkarib Babikir Gabir Kaballo Sami Ahmed Khalid Abdalazim Higawee Alaa AbdElhabib Alaa AlaaAldeen Aled O. Phillips Amal Mahmoud Saeed |
| author_facet | Nour Elkhair Ali Lamis AbdelGadir Kaddam Suad Yousif Alkarib Babikir Gabir Kaballo Sami Ahmed Khalid Abdalazim Higawee Alaa AbdElhabib Alaa AlaaAldeen Aled O. Phillips Amal Mahmoud Saeed |
| author_sort | Nour Elkhair Ali |
| collection | DOAJ |
| description | Background. Oxidative processes might increase in patients with end-stage renal disease (ESRD) according to the current literature. Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. Haemodialysis (HD) is life-saving procedure, nevertheless it is an active chronic inflammatory status that could augment cardiovascular disease and increase mortality. Gum Arabic (GA) has been claimed to act as an antioxidant and anti-inflammatory agent in experimental studies and clinical trials. Therefore, we assumed GA supplementation among haemodialysis patients would reduce oxidative stress and consequently reduce the state of chronic inflammatory activation associated with haemodialysis. Methods. Forty end-stage renal failure (ESRF) patients aged 18–80 years who were on regular haemodialysis in Arif Renal Center, Omdurman, Sudan, were recruited. All recruited patients met the inclusion criteria and signed informed consent prior to enrolment. The patients received 30 g/day of GA for 12 weeks. C-reactive protein (CRP) and complete blood count (CBC) were measured as baseline and monthly. Total antioxidant capacity (TAC) and oxidative stress marker malondialdehyde (MDA) levels were measured before and after GA intake. Ethical approval from the National Medicines and Poisons Board was obtained. Results. Gum Arabic significantly augmented total antioxidant capacity level (P<0.001) (95% CI, 0.408–0.625) and also attenuated oxidative marker MDA and C-reactive protein (P<0.001). Conclusions. GA has revealed potent antioxidative and anti-inflammatory properties in haemodialysis patients. Oral digestion of GA (30 g/day) decreased oxidative stress and inflammatory markers among haemodialysis patients. Trial registration. ClinicalTrials.gov Identifier: NCT03214692, registered 11 July 2017 (prospective registration). |
| format | Article |
| id | doaj-art-ea09b1672502453694092c37a85a72ec |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-ea09b1672502453694092c37a85a72ec2025-02-03T06:07:37ZengWileyInternational Journal of Nephrology2090-214X2090-21582020-01-01202010.1155/2020/72146737214673Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II TrialNour Elkhair Ali0Lamis AbdelGadir Kaddam1Suad Yousif Alkarib2Babikir Gabir Kaballo3Sami Ahmed Khalid4Abdalazim Higawee5Alaa AbdElhabib6Alaa AlaaAldeen7Aled O. Phillips8Amal Mahmoud Saeed9Department of Physiology, Faculty of Medicine, Alneelain University, Khartoum, SudanDepartment of Physiology, Faculty of Medicine, Alneelain University, Khartoum, SudanDepartment of Pharmaceutics, College of Pharmacy, Karary University, Khartoum, SudanNephrology Unit, Military Hospital Omdurman, SudanFaculty of Pharmacy, University of Science & Technology, Omdurman, SudanNephrology Unit, Military Hospital Omdurman, SudanNephrology Unit, Military Hospital Omdurman, SudanNephrology Unit, Military Hospital Omdurman, SudanInstitute of Nephrology, Cardiff University School of Medicine, Cardiff, UKDepartment of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, SudanBackground. Oxidative processes might increase in patients with end-stage renal disease (ESRD) according to the current literature. Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. Haemodialysis (HD) is life-saving procedure, nevertheless it is an active chronic inflammatory status that could augment cardiovascular disease and increase mortality. Gum Arabic (GA) has been claimed to act as an antioxidant and anti-inflammatory agent in experimental studies and clinical trials. Therefore, we assumed GA supplementation among haemodialysis patients would reduce oxidative stress and consequently reduce the state of chronic inflammatory activation associated with haemodialysis. Methods. Forty end-stage renal failure (ESRF) patients aged 18–80 years who were on regular haemodialysis in Arif Renal Center, Omdurman, Sudan, were recruited. All recruited patients met the inclusion criteria and signed informed consent prior to enrolment. The patients received 30 g/day of GA for 12 weeks. C-reactive protein (CRP) and complete blood count (CBC) were measured as baseline and monthly. Total antioxidant capacity (TAC) and oxidative stress marker malondialdehyde (MDA) levels were measured before and after GA intake. Ethical approval from the National Medicines and Poisons Board was obtained. Results. Gum Arabic significantly augmented total antioxidant capacity level (P<0.001) (95% CI, 0.408–0.625) and also attenuated oxidative marker MDA and C-reactive protein (P<0.001). Conclusions. GA has revealed potent antioxidative and anti-inflammatory properties in haemodialysis patients. Oral digestion of GA (30 g/day) decreased oxidative stress and inflammatory markers among haemodialysis patients. Trial registration. ClinicalTrials.gov Identifier: NCT03214692, registered 11 July 2017 (prospective registration).http://dx.doi.org/10.1155/2020/7214673 |
| spellingShingle | Nour Elkhair Ali Lamis AbdelGadir Kaddam Suad Yousif Alkarib Babikir Gabir Kaballo Sami Ahmed Khalid Abdalazim Higawee Alaa AbdElhabib Alaa AlaaAldeen Aled O. Phillips Amal Mahmoud Saeed Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial International Journal of Nephrology |
| title | Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial |
| title_full | Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial |
| title_fullStr | Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial |
| title_full_unstemmed | Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial |
| title_short | Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial |
| title_sort | gum arabic acacia senegal augmented total antioxidant capacity and reduced c reactive protein among haemodialysis patients in phase ii trial |
| url | http://dx.doi.org/10.1155/2020/7214673 |
| work_keys_str_mv | AT nourelkhairali gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT lamisabdelgadirkaddam gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT suadyousifalkarib gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT babikirgabirkaballo gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT samiahmedkhalid gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT abdalazimhigawee gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT alaaabdelhabib gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT alaaalaaaldeen gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT aledophillips gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial AT amalmahmoudsaeed gumarabicacaciasenegalaugmentedtotalantioxidantcapacityandreducedcreactiveproteinamonghaemodialysispatientsinphaseiitrial |