Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.

Reproductive disorders that are common/increasing in prevalence in human males may arise because of deficient androgen production/action during a fetal 'masculinization programming window'. We identify a potentially important role for Chicken Ovalbumin Upstream Promoter-Transcription Facto...

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Bibliographic Details
Main Authors: Sander van den Driesche, Marion Walker, Chris McKinnell, Hayley M Scott, Sharon L Eddie, Rod T Mitchell, Jonathan R Seckl, Amanda J Drake, Lee B Smith, Richard A Anderson, Richard M Sharpe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0037064&type=printable
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