Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

Abstract A pro-tumorigenic role for adipocytes has been identified in breast cancer, and reliance on fatty acid catabolism found in aggressive tumors. The molecular mechanisms by which tumor cells coopt neighboring adipocytes, however, remain incompletely understood. Here, we describe a direct inter...

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Main Authors: Jeremy Williams, Roman Camarda, Serghei Malkov, Lisa J. Zimmerman, Suzanne Manning, Dvir Aran, Andrew Beardsley, Daniel Van de Mark, Rachel Nakagawa, Yong Chen, Charles Berdan, Sharon M. Louie, Celine Mahieu, Daphne Superville, Juliane Winkler, Elizabeth Willey, Erica J. Hutchins, John D. Gagnon, Seda Kilinc Avsaroglu, Kosaku Shinoda, Matthew Gruner, Hiroshi Nishida, K. Mark Ansel, Zena Werb, Daniel K. Nomura, Shingo Kajimura, Atul J. Butte, Melinda E. Sanders, Daniel C. Liebler, Hope S. Rugo, Gregor Krings, John A. Shepherd, Andrei Goga
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62486-3
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