RNAi epimutations conferring antifungal drug resistance are inheritable

Abstract Epimutations modify gene expression and lead to phenotypic variation while the encoding DNA sequence remains unchanged. Epimutations mediated by RNA interference (RNAi) and/or chromatin modifications can confer antifungal drug resistance and may impact virulence traits in fungi. However, wh...

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Bibliographic Details
Main Authors: Carlos Pérez-Arques, María Isabel Navarro-Mendoza, Ziyan Xu, Grit Walther, Joseph Heitman
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62572-6
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