Log BB Prediction Models Using TLC and HPLC Retention Values as Protein Affinity Data

Log BB Prediction Models Using TLC and HPLC Retention Values as Protein Affinity Data

Background: The penetration of drugs through the blood–brain barrier is one of the key pharmacokinetic aspects of centrally acting active substances and other drugs in terms of the occurrence of side effects on the central nervous system. In our research, several regression models were constructed i...

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Bibliographic Details
Main Authors: Karolina Wanat, Klaudia Michalak, Elżbieta Brzezińska
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
log BB
CNS penetration
regression models
chromatographic data
affinity chromatography
serum albumin
Online Access:https://www.mdpi.com/1999-4923/16/12/1534
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