Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women
We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactiv...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/904878 |
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| author | O. A. Matvienko D. L. Alekel S. N. Bhupathiraju H. Hofmann L. M. Ritland M. B. Reddy M. D. Van Loan C. D. Perry |
| author_facet | O. A. Matvienko D. L. Alekel S. N. Bhupathiraju H. Hofmann L. M. Ritland M. B. Reddy M. D. Van Loan C. D. Perry |
| author_sort | O. A. Matvienko |
| collection | DOAJ |
| description | We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except for homocysteine, each cardiometabolic outcome model was significant (overall
𝑃-values from ≤.0001 to .0028). Androidal fat mass was typically the strongest covariate in each model. Isoflavone treatment did not influence any of the outcomes. Thus, androidal fat mass, but not isoflavonetreatment, is likely to alter the cardiometabolic profile in healthy postmenopausal women. |
| format | Article |
| id | doaj-art-e9fbf253682b4f1196577fe07fbe5b2a |
| institution | DOAJ |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-e9fbf253682b4f1196577fe07fbe5b2a2025-08-20T03:20:40ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/904878904878Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal WomenO. A. Matvienko0D. L. Alekel1S. N. Bhupathiraju2H. Hofmann3L. M. Ritland4M. B. Reddy5M. D. Van Loan6C. D. Perry7School of Health, Physical Education and Leisure Services, 133 Wellness/Recreation Center, University of Northern Iowa, Cedar Falls, IA 50614-0241, USAFood Science and Human Nutrition, Human Nutritional Sciences Building, Iowa State University, Ames, IA 50011-1123, USAFood Science and Human Nutrition, Human Nutritional Sciences Building, Iowa State University, Ames, IA 50011-1123, USADepartment of Statistics, 2413 Snedecor/2624C Howe, Iowa State University, Ames, IA 50011, USAFood Science and Human Nutrition, Human Nutritional Sciences Building, Iowa State University, Ames, IA 50011-1123, USAFood Science and Human Nutrition, Human Nutritional Sciences Building, Iowa State University, Ames, IA 50011-1123, USAWestern Human Nutrition Research Center, University of California, Davis, CA 95616, USAFood Science and Human Nutrition, Human Nutritional Sciences Building, Iowa State University, Ames, IA 50011-1123, USAWe hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except for homocysteine, each cardiometabolic outcome model was significant (overall 𝑃-values from ≤.0001 to .0028). Androidal fat mass was typically the strongest covariate in each model. Isoflavone treatment did not influence any of the outcomes. Thus, androidal fat mass, but not isoflavonetreatment, is likely to alter the cardiometabolic profile in healthy postmenopausal women.http://dx.doi.org/10.4061/2011/904878 |
| spellingShingle | O. A. Matvienko D. L. Alekel S. N. Bhupathiraju H. Hofmann L. M. Ritland M. B. Reddy M. D. Van Loan C. D. Perry Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women Cardiology Research and Practice |
| title | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
| title_full | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
| title_fullStr | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
| title_full_unstemmed | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
| title_short | Androidal Fat Dominates in Predicting Cardiometabolic Risk in Postmenopausal Women |
| title_sort | androidal fat dominates in predicting cardiometabolic risk in postmenopausal women |
| url | http://dx.doi.org/10.4061/2011/904878 |
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