Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Abstract Effective immune responses in both the spleen and the tumor microenvironment are crucial for cancer immunotherapy. However, delivery of neoantigen peptide vaccines to antigen‐presenting cells (APCs) at these sites remains challenging. In this study, LNPsD18, a cationic liposomal formulation...

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Bibliographic Details
Main Authors: Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
neoantigen vaccine
spleen‐tumor immunity
targeting antigen‐presenting cells
tumor microenvironment
tumor‐associated macrophages
Online Access:https://doi.org/10.1002/advs.202500021
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