Immunological tolerance in breast cancer: some reasons for development
Immunological tolerance is one of the reasons for the development and progression of malignant tumors. The tumor immune cycle regulates the normal antitumor immune response, and it’s disruption is responsible for the development of immunological tolerance. This article provides a review of russian a...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2024-10-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/705 |
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| author | E. V. Kayukova E. S. Bolotov |
| author_facet | E. V. Kayukova E. S. Bolotov |
| author_sort | E. V. Kayukova |
| collection | DOAJ |
| description | Immunological tolerance is one of the reasons for the development and progression of malignant tumors. The tumor immune cycle regulates the normal antitumor immune response, and it’s disruption is responsible for the development of immunological tolerance. This article provides a review of russian and foreign literature published in databases such as PubMed, Medline, and Cochrane, eLibrary in the last 5 years, focusing on the emergence of immunological tolerance in breast cancer from the perspective of disrupted regulation of tumor immune cycle phases: expression of antigens on the surface of tumor cells, cancer antigen presentation, priming and activation T cells, immune infiltration of the tumor site, recognition, and elimination of tumor cells. Understanding the mechanisms underlying tumor immune cycle disruption is important for identifying new immunopathogenetic links in the development of breast cancer, as well as identifying targets to improve the effectiveness of therapy for advanced breast cancer. |
| format | Article |
| id | doaj-art-e9f73c9efb6147199ea6dde2af4843fe |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-e9f73c9efb6147199ea6dde2af4843fe2025-08-20T03:38:02ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872024-10-01113243110.17650/2313-805X-2024-11-3-24-31336Immunological tolerance in breast cancer: some reasons for developmentE. V. Kayukova0E. S. Bolotov1Chita State Medical Academy, Ministry of Health of RussiaChita State Medical Academy, Ministry of Health of RussiaImmunological tolerance is one of the reasons for the development and progression of malignant tumors. The tumor immune cycle regulates the normal antitumor immune response, and it’s disruption is responsible for the development of immunological tolerance. This article provides a review of russian and foreign literature published in databases such as PubMed, Medline, and Cochrane, eLibrary in the last 5 years, focusing on the emergence of immunological tolerance in breast cancer from the perspective of disrupted regulation of tumor immune cycle phases: expression of antigens on the surface of tumor cells, cancer antigen presentation, priming and activation T cells, immune infiltration of the tumor site, recognition, and elimination of tumor cells. Understanding the mechanisms underlying tumor immune cycle disruption is important for identifying new immunopathogenetic links in the development of breast cancer, as well as identifying targets to improve the effectiveness of therapy for advanced breast cancer.https://umo.abvpress.ru/jour/article/view/705immune tolerancebreast cancertumor immune cyclemetabolome |
| spellingShingle | E. V. Kayukova E. S. Bolotov Immunological tolerance in breast cancer: some reasons for development Успехи молекулярной онкологии immune tolerance breast cancer tumor immune cycle metabolome |
| title | Immunological tolerance in breast cancer: some reasons for development |
| title_full | Immunological tolerance in breast cancer: some reasons for development |
| title_fullStr | Immunological tolerance in breast cancer: some reasons for development |
| title_full_unstemmed | Immunological tolerance in breast cancer: some reasons for development |
| title_short | Immunological tolerance in breast cancer: some reasons for development |
| title_sort | immunological tolerance in breast cancer some reasons for development |
| topic | immune tolerance breast cancer tumor immune cycle metabolome |
| url | https://umo.abvpress.ru/jour/article/view/705 |
| work_keys_str_mv | AT evkayukova immunologicaltoleranceinbreastcancersomereasonsfordevelopment AT esbolotov immunologicaltoleranceinbreastcancersomereasonsfordevelopment |