Real-time assessment of circulating tumor cells refines the indication for HER2-targeted therapy in metastatic gastric cancer

Real-time assessment of circulating tumor cells refines the indication for HER2-targeted therapy in metastatic gastric cancer

Abstract HER2-targeted therapies have improved outcomes in metastatic gastric cancer (mGC), yet assessment of HER2 status in tumor tissues remains limited by heterogeneity and temporal changes. This study aimed to evaluate real-time HER2 expression on circulating tumor cells (CTCs) using the On-chip...

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Bibliographic Details
Main Authors: Yasuaki Kimura, Koichi Suzuki, Sawako Tamaki, Iku Abe, Yuhei Endo, Kosuke Ichida, Yuta Muto, Fumiaki Watanabe, Masaaki Saito, Kazuo Takeda, Toshiki Rikiyama
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Advanced gastric cancer
Circulating tumor cells
HER2
Liquid biopsy
Online Access:https://doi.org/10.1038/s41598-025-06913-x
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