Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy
Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM2.5 and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different constituents of PM2.5. Thus, we performed this retrospective an...
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Elsevier
2025-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132500346X |
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| author | Cheng Li Ying-Zhou Ge Yan-Hui Hao Jing-Jing Xu Si-Wei Zhang Si-Yue Chen Hai-Dong Kan Xia Meng He-Feng Huang Yan-Ting Wu |
| author_facet | Cheng Li Ying-Zhou Ge Yan-Hui Hao Jing-Jing Xu Si-Wei Zhang Si-Yue Chen Hai-Dong Kan Xia Meng He-Feng Huang Yan-Ting Wu |
| author_sort | Cheng Li |
| collection | DOAJ |
| description | Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM2.5 and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different constituents of PM2.5. Thus, we performed this retrospective analysis among 160,544 pregnant women who delivered between 2014 and 2020, to further estimate the impact of different constituents of PM2.5, as well as the duration of sunlight, on ICP via generalized linear models. During the three months prior to conception, the adjusted odds ratios (aORs) for ICP were 1.176 (95 % CI: 1.066, 1.298) for a 10 μg/m3 increase in PM2.5, 1.080 (95 % CI: 1.026, 1.138) for a 1 μg/m3 increase in sulfate (SO42–), 1.069 (95 % CI: 1.025, 1.115) for a 1 μg/m3 increase in organic matter (OM), 1.274 (95 % CI: 1.049, 1.546) for a 1 μg/m3 increase in black carbon (BC), and 1.213 (95 % CI: 1.088, 1.353) for a 1-hour decrease in sunlight duration. In addition, during the preconception period, increased exposure to PM2.5 constituents (including SO42–, OM, and BC) and decreased sunlight duration interactively associated with ICP. Moreover, exposure to OM during the first trimester (aOR=1.043, 95 % CI: 1.004, 1.083) and to BC during both the first trimester (aOR=1.201, 95 % CI: 1.000, 1.442) and the second trimester (aOR=1.278, 95 % CI: 1.048, 1.558) were found to elevate the risk of ICP. In the future, women preparing to conceive should increase sunlight exposure and avoid exposure to air pollution, and the constituents related to anthropogenic emissions should be controlled to prevent these associations. |
| format | Article |
| id | doaj-art-e9ec7741c2e247cb9a7f2508919c2fa8 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e9ec7741c2e247cb9a7f2508919c2fa82025-08-20T03:42:56ZengElsevierEcotoxicology and Environmental Safety0147-65132025-03-0129311801010.1016/j.ecoenv.2025.118010Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancyCheng Li0Ying-Zhou Ge1Yan-Hui Hao2Jing-Jing Xu3Si-Wei Zhang4Si-Yue Chen5Hai-Dong Kan6Xia Meng7He-Feng Huang8Yan-Ting Wu9Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China; Department of Reproductive Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, ChinaSchool of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China; Corresponding author.Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), Shanghai 200030, China; Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Corresponding authors at: Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China.Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China; Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), Shanghai 200030, China; Corresponding authors at: Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China.Few studies have reported an association between intrahepatic cholestasis of pregnancy (ICP) and preconception exposure to PM2.5 and sunlight duration, but there has been no in-depth analysis of the correlation between ICP and different constituents of PM2.5. Thus, we performed this retrospective analysis among 160,544 pregnant women who delivered between 2014 and 2020, to further estimate the impact of different constituents of PM2.5, as well as the duration of sunlight, on ICP via generalized linear models. During the three months prior to conception, the adjusted odds ratios (aORs) for ICP were 1.176 (95 % CI: 1.066, 1.298) for a 10 μg/m3 increase in PM2.5, 1.080 (95 % CI: 1.026, 1.138) for a 1 μg/m3 increase in sulfate (SO42–), 1.069 (95 % CI: 1.025, 1.115) for a 1 μg/m3 increase in organic matter (OM), 1.274 (95 % CI: 1.049, 1.546) for a 1 μg/m3 increase in black carbon (BC), and 1.213 (95 % CI: 1.088, 1.353) for a 1-hour decrease in sunlight duration. In addition, during the preconception period, increased exposure to PM2.5 constituents (including SO42–, OM, and BC) and decreased sunlight duration interactively associated with ICP. Moreover, exposure to OM during the first trimester (aOR=1.043, 95 % CI: 1.004, 1.083) and to BC during both the first trimester (aOR=1.201, 95 % CI: 1.000, 1.442) and the second trimester (aOR=1.278, 95 % CI: 1.048, 1.558) were found to elevate the risk of ICP. In the future, women preparing to conceive should increase sunlight exposure and avoid exposure to air pollution, and the constituents related to anthropogenic emissions should be controlled to prevent these associations.http://www.sciencedirect.com/science/article/pii/S014765132500346XPM2.5Organic matterBlack carbonPreconception exposureSunlight durationIntrahepatic cholestasis of pregnancy |
| spellingShingle | Cheng Li Ying-Zhou Ge Yan-Hui Hao Jing-Jing Xu Si-Wei Zhang Si-Yue Chen Hai-Dong Kan Xia Meng He-Feng Huang Yan-Ting Wu Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy Ecotoxicology and Environmental Safety PM2.5 Organic matter Black carbon Preconception exposure Sunlight duration Intrahepatic cholestasis of pregnancy |
| title | Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| title_full | Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| title_fullStr | Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| title_full_unstemmed | Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| title_short | Associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| title_sort | associations between fine particulate matter and its constituents and intrahepatic cholestasis of pregnancy |
| topic | PM2.5 Organic matter Black carbon Preconception exposure Sunlight duration Intrahepatic cholestasis of pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S014765132500346X |
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