Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections
Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and micron...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/11/316 |
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| author | Juhaina M. Abu Ershaid Han Zhang May Tayyem Akmal H. Sabri Ryan F. Donnelly Lalitkumar K. Vora |
| author_facet | Juhaina M. Abu Ershaid Han Zhang May Tayyem Akmal H. Sabri Ryan F. Donnelly Lalitkumar K. Vora |
| author_sort | Juhaina M. Abu Ershaid |
| collection | DOAJ |
| description | Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles. Methods: This study focused on the use of sodium alginate MNs for vancomycin delivery directly to the site of infection via a cost-effective micromolding technique. Dissolving polymeric MNs made of sodium alginate and loaded with vancomycin were fabricated and evaluated in terms of their physical properties, delivery ability, and antimicrobial activity. Results: The MNs achieved a 378 μm depth of insertion into ex vivo skin and a 5.0 ± 0 mm zone of inhibition in agar disc diffusion assays. Furthermore, in ex vivo Franz cell experiments, the MNs delivered 34.46 ± 11.31 μg of vancomycin with around 35% efficiency, with 9.88 ± 0.57 μg deposited in the skin after 24 h. Conclusions: These findings suggest that sodium alginate MNs are a viable platform for antimicrobial agent delivery in SSTIs. Future in vivo studies are essential to confirm the safety and effectiveness of this innovative method for clinical use. |
| format | Article |
| id | doaj-art-e9eb1e9014db4e7ead6e89a2b9496495 |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-e9eb1e9014db4e7ead6e89a2b94964952025-08-20T02:47:58ZengMDPI AGJournal of Functional Biomaterials2079-49832024-10-01151131610.3390/jfb15110316Sodium Alginate Microneedles Loaded with Vancomycin for Skin InfectionsJuhaina M. Abu Ershaid0Han Zhang1May Tayyem2Akmal H. Sabri3Ryan F. Donnelly4Lalitkumar K. Vora5School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKSchool of Pharmacy, Department of Pharmaceutical Technology and Cosmetics, Middle East University, Airport Road, Amman 11831, JordanSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKBackground: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles. Methods: This study focused on the use of sodium alginate MNs for vancomycin delivery directly to the site of infection via a cost-effective micromolding technique. Dissolving polymeric MNs made of sodium alginate and loaded with vancomycin were fabricated and evaluated in terms of their physical properties, delivery ability, and antimicrobial activity. Results: The MNs achieved a 378 μm depth of insertion into ex vivo skin and a 5.0 ± 0 mm zone of inhibition in agar disc diffusion assays. Furthermore, in ex vivo Franz cell experiments, the MNs delivered 34.46 ± 11.31 μg of vancomycin with around 35% efficiency, with 9.88 ± 0.57 μg deposited in the skin after 24 h. Conclusions: These findings suggest that sodium alginate MNs are a viable platform for antimicrobial agent delivery in SSTIs. Future in vivo studies are essential to confirm the safety and effectiveness of this innovative method for clinical use.https://www.mdpi.com/2079-4983/15/11/316microneedlesvancomycinsodium alginateMRSAskin infections |
| spellingShingle | Juhaina M. Abu Ershaid Han Zhang May Tayyem Akmal H. Sabri Ryan F. Donnelly Lalitkumar K. Vora Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections Journal of Functional Biomaterials microneedles vancomycin sodium alginate MRSA skin infections |
| title | Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections |
| title_full | Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections |
| title_fullStr | Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections |
| title_full_unstemmed | Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections |
| title_short | Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections |
| title_sort | sodium alginate microneedles loaded with vancomycin for skin infections |
| topic | microneedles vancomycin sodium alginate MRSA skin infections |
| url | https://www.mdpi.com/2079-4983/15/11/316 |
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