Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective
Objectives: To assess the mid-term safety and efficacy of transthoracic perimembranous ventricular septal defect (Pm-VSD) closure using a new biodegradable device. Implantation entailed right subaxillary minithoracotomy under transesophageal echocardiography guidance. Methods: Between October 2019 a...
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| Language: | English |
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Elsevier
2023-02-01
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| Series: | JTCVS Techniques |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666250722005909 |
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| author | Shubo Song, MD Zehua Shao, MD Taibing Fan, Prof Bin Li, MD Weijie Liang, MD Haoju Dong, MD Kaiyuan Wu, MD Manman Hu, MD Yu Han, MD Cunying Cui, MD |
| author_facet | Shubo Song, MD Zehua Shao, MD Taibing Fan, Prof Bin Li, MD Weijie Liang, MD Haoju Dong, MD Kaiyuan Wu, MD Manman Hu, MD Yu Han, MD Cunying Cui, MD |
| author_sort | Shubo Song, MD |
| collection | DOAJ |
| description | Objectives: To assess the mid-term safety and efficacy of transthoracic perimembranous ventricular septal defect (Pm-VSD) closure using a new biodegradable device. Implantation entailed right subaxillary minithoracotomy under transesophageal echocardiography guidance. Methods: Between October 2019 and January 2020, 13 patients (males, 5; mean age, 3.6 ± 2.5 years) with Pm-VSDs underwent transthoracic device closures at Zhengzhou University Central China Fuwai Hospital as described previously. Delivery pathways were established by manipulating a hollow probe from right atrium through tricuspid valve to right ventricle and then through VSDs to left ventricle, whereupon installation took place. Results: All occluder implantations were successfully executed. Mean defect size was 4.1 ± 1.0 mm, and mean device waist size was 5.2 ± 1.1 mm. One patient (7.7%) with 1.5-mm residual shunt showed complete closure at discharge. There was 1 instance of postoperative incomplete right bundle branch block, which converted to complete right bundle branch block at month 1. During patient follow-up (mean, 24.6 ± 0.8 months), no device dislocations, new residual shunts, new valvular regurgitation, or detectable atrioventricular block ensued. Conclusions: Closure of Pm-VSDs using a novel, fully biodegradable occluder in the manner described has proven safe and effective at mid-term follow-up. Long-term safety and efficacy of this device must be further corroborated in a large patient cohort going forward. |
| format | Article |
| id | doaj-art-e9ea38d61d5245bdbeb273ebaa375f06 |
| institution | DOAJ |
| issn | 2666-2507 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Techniques |
| spelling | doaj-art-e9ea38d61d5245bdbeb273ebaa375f062025-08-20T03:04:53ZengElsevierJTCVS Techniques2666-25072023-02-011713313710.1016/j.xjtc.2022.11.010Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspectiveShubo Song, MD0Zehua Shao, MD1Taibing Fan, Prof2Bin Li, MD3Weijie Liang, MD4Haoju Dong, MD5Kaiyuan Wu, MD6Manman Hu, MD7Yu Han, MD8Cunying Cui, MD9Department of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, China; Address for reprints: Taibing Fan, Prof, Department of Children's Heart Center, Zhengzhou University People's Hospital, No. 7 Weiwu Rd, Zhengzhou 450000, China.Department of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Children's Heart Center, Zhengzhou University People's Hospital, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaDepartment of Ultrasound, Zhengzhou University Central China Fuwai Hospital, Zhengzhou, ChinaObjectives: To assess the mid-term safety and efficacy of transthoracic perimembranous ventricular septal defect (Pm-VSD) closure using a new biodegradable device. Implantation entailed right subaxillary minithoracotomy under transesophageal echocardiography guidance. Methods: Between October 2019 and January 2020, 13 patients (males, 5; mean age, 3.6 ± 2.5 years) with Pm-VSDs underwent transthoracic device closures at Zhengzhou University Central China Fuwai Hospital as described previously. Delivery pathways were established by manipulating a hollow probe from right atrium through tricuspid valve to right ventricle and then through VSDs to left ventricle, whereupon installation took place. Results: All occluder implantations were successfully executed. Mean defect size was 4.1 ± 1.0 mm, and mean device waist size was 5.2 ± 1.1 mm. One patient (7.7%) with 1.5-mm residual shunt showed complete closure at discharge. There was 1 instance of postoperative incomplete right bundle branch block, which converted to complete right bundle branch block at month 1. During patient follow-up (mean, 24.6 ± 0.8 months), no device dislocations, new residual shunts, new valvular regurgitation, or detectable atrioventricular block ensued. Conclusions: Closure of Pm-VSDs using a novel, fully biodegradable occluder in the manner described has proven safe and effective at mid-term follow-up. Long-term safety and efficacy of this device must be further corroborated in a large patient cohort going forward.http://www.sciencedirect.com/science/article/pii/S2666250722005909ventricular septal defectbiodegradable deviceechocardiographytransthoracic interventionminimally invasive surgery |
| spellingShingle | Shubo Song, MD Zehua Shao, MD Taibing Fan, Prof Bin Li, MD Weijie Liang, MD Haoju Dong, MD Kaiyuan Wu, MD Manman Hu, MD Yu Han, MD Cunying Cui, MD Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective JTCVS Techniques ventricular septal defect biodegradable device echocardiography transthoracic intervention minimally invasive surgery |
| title | Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective |
| title_full | Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective |
| title_fullStr | Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective |
| title_full_unstemmed | Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective |
| title_short | Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closureCentral MessagePerspective |
| title_sort | favorable mid term performance of fully biodegradable implantable device for ventricular septal defect closurecentral messageperspective |
| topic | ventricular septal defect biodegradable device echocardiography transthoracic intervention minimally invasive surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666250722005909 |
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