TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis

TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis

Abstract Background Traumatic brain injury (TBI) is characterized by high mortality and disability rates. Disease-associated microglia (DAM) are a newly discovered subtype of microglia. However, their presence and function in the acute phase of TBI remain unclear. Although glycolysis is important fo...

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Bibliographic Details
Main Authors: Lin Wang, Diqing Ouyang, Lin Li, Yunchuan Cao, Yingwen Wang, Nina Gu, Zhaosi Zhang, Zhao Li, Shuang Tang, Hui Tang, Yuan Zhang, Xiaochuan Sun, Jin Yan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Traumatic brain injury
Microglia
Disease-associated microglia
Glycolysis
Triggering receptor expressed on myeloid cells 2
Online Access:https://doi.org/10.1186/s12974-025-03337-2
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