EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS
Objective: to analyze the results of focused ultrasound ablation (MRgFUS) of uterine fibroids and to evaluate the factors affecting the long-term results of treatment.Material and methods. Retrospective analysis of 67 FUS ablations (67 women, 94 fibroids) was performed. The observation period after...
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Luchevaya Diagnostika, LLC
2017-05-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/208 |
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| author | E. S. Zagvozdkin V. E. Sinitsyn E. A. Mershina |
| author_facet | E. S. Zagvozdkin V. E. Sinitsyn E. A. Mershina |
| author_sort | E. S. Zagvozdkin |
| collection | DOAJ |
| description | Objective: to analyze the results of focused ultrasound ablation (MRgFUS) of uterine fibroids and to evaluate the factors affecting the long-term results of treatment.Material and methods. Retrospective analysis of 67 FUS ablations (67 women, 94 fibroids) was performed. The observation period after FUS was up to 36 months. Characteristics of fibroids (standardized signal intensity (SSI) and signal heterogeneity in T2-WI, maximum diameter, volume, nonperfused volume (NPV), coefficients of volume and NPV dynamics (CDV, CDNPV), MR-type) were assessed by MRI. Standardization of the fibroid signal intensity was performed by using the signal intensity from iliac muscle. CDV, CDNPV were calculated as the ratio of fibroids volume and NPV at the time of control MRI to their initial values.Results. Post treatment NPV ratio was 57.1 ± 22.5%. The maximal significant reduction of fibroids volume and NPV was detected by 12 months after FUS (52.1% and 85.8%). CDV and CDNPV showed significant (p<0.05) correlation with post treatment NPV ratio (r=-0.5 and r=0.37), fibroids volume (r=0.28 and r=0.49) and maximum diameter (r=0.26 and r=0.49). Fibroids with NPV ≥50% and volume <150 cm3 were characterized by the highest rate of volume reduction. Fibroids with NPV≥75% and volume >100 cm3 were characterized by the lowest rate of NPV reduction. The maximal reduction of volume during the observation period was detected in fibroids with NPV≥75% and volume <100 cm3, the minimal – in fibroids with NPV<25% and volume >150 cm3.Conclusion. The dynamics of fibroids volume and NPV after MRgFUS depends on initial values of these characteristics. |
| format | Article |
| id | doaj-art-e9e5d5590e064c28a3042ef059f8bd80 |
| institution | DOAJ |
| issn | 0042-4676 2619-0478 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj-art-e9e5d5590e064c28a3042ef059f8bd802025-08-20T03:09:00ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782017-05-01982869110.20862/0042-4676-2017-98-2-86-91169EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDSE. S. Zagvozdkin0V. E. Sinitsyn1E. A. Mershina2Federal Center of Treatment and Rehabilitation, Ministry of Health of the RFFederal Center of Treatment and Rehabilitation, Ministry of Health of the RFFederal Center of Treatment and Rehabilitation, Ministry of Health of the RFObjective: to analyze the results of focused ultrasound ablation (MRgFUS) of uterine fibroids and to evaluate the factors affecting the long-term results of treatment.Material and methods. Retrospective analysis of 67 FUS ablations (67 women, 94 fibroids) was performed. The observation period after FUS was up to 36 months. Characteristics of fibroids (standardized signal intensity (SSI) and signal heterogeneity in T2-WI, maximum diameter, volume, nonperfused volume (NPV), coefficients of volume and NPV dynamics (CDV, CDNPV), MR-type) were assessed by MRI. Standardization of the fibroid signal intensity was performed by using the signal intensity from iliac muscle. CDV, CDNPV were calculated as the ratio of fibroids volume and NPV at the time of control MRI to their initial values.Results. Post treatment NPV ratio was 57.1 ± 22.5%. The maximal significant reduction of fibroids volume and NPV was detected by 12 months after FUS (52.1% and 85.8%). CDV and CDNPV showed significant (p<0.05) correlation with post treatment NPV ratio (r=-0.5 and r=0.37), fibroids volume (r=0.28 and r=0.49) and maximum diameter (r=0.26 and r=0.49). Fibroids with NPV ≥50% and volume <150 cm3 were characterized by the highest rate of volume reduction. Fibroids with NPV≥75% and volume >100 cm3 were characterized by the lowest rate of NPV reduction. The maximal reduction of volume during the observation period was detected in fibroids with NPV≥75% and volume <100 cm3, the minimal – in fibroids with NPV<25% and volume >150 cm3.Conclusion. The dynamics of fibroids volume and NPV after MRgFUS depends on initial values of these characteristics.https://www.russianradiology.ru/jour/article/view/208uterine fibroidmagnetic resonance imaginglong-term resultsfocused ultrasoundablation |
| spellingShingle | E. S. Zagvozdkin V. E. Sinitsyn E. A. Mershina EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS Вестник рентгенологии и радиологии uterine fibroid magnetic resonance imaging long-term results focused ultrasound ablation |
| title | EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS |
| title_full | EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS |
| title_fullStr | EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS |
| title_full_unstemmed | EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS |
| title_short | EVALUATION OF FACTORS AFFECTING THE LONG-TERM RESULTS OF MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND ABLATION OF UTERINE FIBROIDS |
| title_sort | evaluation of factors affecting the long term results of magnetic resonance imaging guided focused ultrasound ablation of uterine fibroids |
| topic | uterine fibroid magnetic resonance imaging long-term results focused ultrasound ablation |
| url | https://www.russianradiology.ru/jour/article/view/208 |
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