COMPARATIVE STUDY ON THE MEASUREMENT OF LIVER T2* VALUES OF THALASSEMIA PATIENTS AND THE CLINICAL GRADING OF LIVER IRON CONCENTRATION BY DIFFERENT POST-PROCESSING SOFTWARE

COMPARATIVE STUDY ON THE MEASUREMENT OF LIVER T2* VALUES OF THALASSEMIA PATIENTS AND THE CLINICAL GRADING OF LIVER IRON CONCENTRATION BY DIFFERENT POST-PROCESSING SOFTWARE

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Objective: To explore the relationship between the liver T2* values of thalassemia patients measured by Circle Cardiovascular Imaging CVI42 (CVI42), CMRtools / Thalassemia Tools (CMRtools) and Excel spreadsheet (Excel), and the three software's accuracy in clinical grading of liver iron concen...

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Bibliographic Details
Main Authors: Peng Peng, Fengming XU, Jixing YI, Bumin LIANG, Cheng TANG, Qing FENG
Format: Article
Language:English
Published: PAGEPress Publications 2022-10-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
Thalassemia; liver iron concentration; comparative study; iron overload
Online Access:http://mjhid.org/index.php/mjhid/article/view/5033
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Summary:Objective: To explore the relationship between the liver T2* values of thalassemia patients measured by Circle Cardiovascular Imaging CVI42 (CVI42), CMRtools / Thalassemia Tools (CMRtools) and Excel spreadsheet (Excel), and the three software's accuracy in clinical grading of liver iron concentration (LIC). Methods: The liver T2* images thalassemia patients were imported into CVI42 and CMRtools to measure the T2* value. And the signal intensity (SI) of the T2* image, measured in the MR scanning equipment, was input into Excel to calculate T2* value. The relationship of the T2* values measured by the above three software were compared. And LIC clinical grading was performed on the three measured T2* value results, and the LIC (LICF) provided by FerriScan was used as the reference standard to compare the accuracy of the three grading results. Results: There was no statistical difference between the T2* values measured by CVI42, CMRtools and Excel (P>0.05), but there was a high degree of consistency between them (P<0.05), and there was a high linear positive correlation between the them (P<0.05). There was no statistical difference between the LIC grading results of CVI42 and CMRtools and the LICF grading results (P>0.05). There is a significant difference between the LIC grading results of Excel and the LICF grading results (P<0.05). Conclusion: The liver T2* values measured by CVI42, CMRtools and Excel are equivalent. However, CVI42 and CMRtools have better diagnostic accuracy for LIC clinical grade, while Excel has worse diagnostic accuracy. Keywords: THALASSEMIA; lIVER T2 VALUE; 
ISSN:2035-3006

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