Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity
Numerous blood biomarkers are altered in COVID-19 patients; however, no early biochemical markers are currently being used in clinical practice to predict COVID-19 severity. COVID-19, the most recent pandemic, is caused by the SRS-CoV-2 coronavirus. The study was aimed to identify patient groups w...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2022-12-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7454 |
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| author | Suhayla K. Mohammed Muzahem Mohialdeen Taha Ekhlass M. Taha Massara Najim Abdulla Mohammad |
| author_facet | Suhayla K. Mohammed Muzahem Mohialdeen Taha Ekhlass M. Taha Massara Najim Abdulla Mohammad |
| author_sort | Suhayla K. Mohammed |
| collection | DOAJ |
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Numerous blood biomarkers are altered in COVID-19 patients; however, no early biochemical markers are currently being used in clinical practice to predict COVID-19 severity. COVID-19, the most recent pandemic, is caused by the SRS-CoV-2 coronavirus. The study was aimed to identify patient groups with a high and low risk of developing COVID-19 using a cluster analysis of several biomarkers. 137 women with confirmed SARS CoV-2 RNA testing were collected and analyzed for biochemical profiles. Two-dimensional automated hierarchy clustering of all biomarkers was applied, and patients were sorted into classes. Biochemistry marker variations (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) have split COVID-19 patients into two groups(severe cases and non-severe cases groups). Ferritin, lactate dehydrogenase LDH, D-dimer and CRP were markedly increased in COVID-19 patients in the first group (severe cases). Our findings imply that early measured levels of (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) are linked to a decreased probability of COVID-19 severity. Elevated levels of this biomarker may predict COVID severity development.
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| format | Article |
| id | doaj-art-e9e52148d12d4d8aac29fd3984635215 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-e9e52148d12d4d8aac29fd39846352152025-08-20T03:19:11ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862022-12-01196(Suppl.)10.21123/bsj.2022.7454Cluster Analysis of Biochemical Markers as Predictor of COVID-19 SeveritySuhayla K. Mohammed 0Muzahem Mohialdeen Taha1Ekhlass M. Taha2Massara Najim Abdulla Mohammad3Collage of Agriculural Engineering Sciences, University of Baghdad, Baghdad, Iraq.Kirkuk University, Kirkuk, Iraq, Consultant orthopedic and spine surgeon- Erbil international hospital.Department of Chemistry, College of Science for Woman, University of Baghdad, Baghdad, Iraq.Ministry of health, Al-Karama teaching hospital, Biochemistry Laboratory, Baghdad, Iraq. Numerous blood biomarkers are altered in COVID-19 patients; however, no early biochemical markers are currently being used in clinical practice to predict COVID-19 severity. COVID-19, the most recent pandemic, is caused by the SRS-CoV-2 coronavirus. The study was aimed to identify patient groups with a high and low risk of developing COVID-19 using a cluster analysis of several biomarkers. 137 women with confirmed SARS CoV-2 RNA testing were collected and analyzed for biochemical profiles. Two-dimensional automated hierarchy clustering of all biomarkers was applied, and patients were sorted into classes. Biochemistry marker variations (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) have split COVID-19 patients into two groups(severe cases and non-severe cases groups). Ferritin, lactate dehydrogenase LDH, D-dimer and CRP were markedly increased in COVID-19 patients in the first group (severe cases). Our findings imply that early measured levels of (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) are linked to a decreased probability of COVID-19 severity. Elevated levels of this biomarker may predict COVID severity development. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7454COVID-19, Cluster Analysis, C- reactive protein CRP, D-dimer, Ferritin, Lactate dehydrogenase LDH |
| spellingShingle | Suhayla K. Mohammed Muzahem Mohialdeen Taha Ekhlass M. Taha Massara Najim Abdulla Mohammad Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity مجلة بغداد للعلوم COVID-19, Cluster Analysis, C- reactive protein CRP, D-dimer, Ferritin, Lactate dehydrogenase LDH |
| title | Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity |
| title_full | Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity |
| title_fullStr | Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity |
| title_full_unstemmed | Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity |
| title_short | Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity |
| title_sort | cluster analysis of biochemical markers as predictor of covid 19 severity |
| topic | COVID-19, Cluster Analysis, C- reactive protein CRP, D-dimer, Ferritin, Lactate dehydrogenase LDH |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7454 |
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