Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study
AIM: To determine the risk factors and time to non-arteric ischemic optic neuropathy (NAION) occurrence among Thai type 2 diabetes mellitus (T2DM) patients. METHODS: A retrospective review of 266 newly diagnosed T2DM cases at Rajavithi Hospital between 2007 and 2016 was conducted to determine time t...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
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| Series: | International Journal of Ophthalmology |
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| author | Parinee Kemchoknatee Duanghathai Tangon Thansit Srisombut |
| author_facet | Parinee Kemchoknatee Duanghathai Tangon Thansit Srisombut |
| author_sort | Parinee Kemchoknatee |
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| description | AIM: To determine the risk factors and time to non-arteric ischemic optic neuropathy (NAION) occurrence among Thai type 2 diabetes mellitus (T2DM) patients. METHODS: A retrospective review of 266 newly diagnosed T2DM cases at Rajavithi Hospital between 2007 and 2016 was conducted to determine time to occurrence of NAION and evaluate associated risk factors. RESULTS: Hypertension and dyslipidemia were the most common pre-existing vascular diseases and there was a significant male predominance in the NAION group. The mean age of the NAION group was significantly higher than that of the group without NAION. A higher proportion of subjects in the NAION group had hypertension, dyslipidemia, high diastolic blood pressure, smokers, and had a small cup-to-disc ratio (CDR). Higher levels of triglycerides and low-density lipoprotein-cholesterol in the group with NAION. Fifty-five patients among 266 participants (20.68%) developed NAION during a mean follow-up time of 81.26±25.04mo. In a multivariable logistic regression analysis, dyslipidemia (OR=8.36, 95%CI, 3.447–20.273, P<0.001), high low density lipoprotein levels (OR=1.017, 95%CI, 1.004–1.029, P=0.009), and small CDR (OR=11.92, 95%CI, 4.477–31.741, P<0.001) were significant risk factors for NAION development. Smoking was the strongest predictive risk (OR=12.843, 95%CI, 3.959–41.659, P<0.001). Vascular complications of T2DM and aspirin were not associated with NAION. CONCLUSION: T2DM patients with dyslipidemia or a small CDR should be carefully followed up as they are at increased risk of developing NAION. |
| format | Article |
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| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj-art-e9e1dc3673bb434ca24c8e92eaa785172025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118229029610.18240/ijo.2025.02.1320250213Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort studyParinee Kemchoknatee0Duanghathai Tangon1Thansit Srisombut2Parinee Kemchoknatee. Department of Ophthalmology, Rangsit University, Rajavithi Hospital, 2, Phaya Thai Rd, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand. parinee.eye52@gmail.comFaculty of Medicine, Rajavithi Hospital, Rangsit University, Thung Phaya Thai, Ratchathewi, Bangkok 10400, ThailandDepartment of Ophthalmology, Rangsit University, Rajavithi Hospital, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand; Faculty of Medicine, Rajavithi Hospital, Rangsit University, Thung Phaya Thai, Ratchathewi, Bangkok 10400, ThailandAIM: To determine the risk factors and time to non-arteric ischemic optic neuropathy (NAION) occurrence among Thai type 2 diabetes mellitus (T2DM) patients. METHODS: A retrospective review of 266 newly diagnosed T2DM cases at Rajavithi Hospital between 2007 and 2016 was conducted to determine time to occurrence of NAION and evaluate associated risk factors. RESULTS: Hypertension and dyslipidemia were the most common pre-existing vascular diseases and there was a significant male predominance in the NAION group. The mean age of the NAION group was significantly higher than that of the group without NAION. A higher proportion of subjects in the NAION group had hypertension, dyslipidemia, high diastolic blood pressure, smokers, and had a small cup-to-disc ratio (CDR). Higher levels of triglycerides and low-density lipoprotein-cholesterol in the group with NAION. Fifty-five patients among 266 participants (20.68%) developed NAION during a mean follow-up time of 81.26±25.04mo. In a multivariable logistic regression analysis, dyslipidemia (OR=8.36, 95%CI, 3.447–20.273, P<0.001), high low density lipoprotein levels (OR=1.017, 95%CI, 1.004–1.029, P=0.009), and small CDR (OR=11.92, 95%CI, 4.477–31.741, P<0.001) were significant risk factors for NAION development. Smoking was the strongest predictive risk (OR=12.843, 95%CI, 3.959–41.659, P<0.001). Vascular complications of T2DM and aspirin were not associated with NAION. CONCLUSION: T2DM patients with dyslipidemia or a small CDR should be carefully followed up as they are at increased risk of developing NAION.http://ies.ijo.cn/en_publish/2025/2/20250213.pdfnon-arteric ischemic optic neuropathysystemic vascular diseasetype 2 diabetes mellitushypertensiondyslipidemia |
| spellingShingle | Parinee Kemchoknatee Duanghathai Tangon Thansit Srisombut Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study International Journal of Ophthalmology non-arteric ischemic optic neuropathy systemic vascular disease type 2 diabetes mellitus hypertension dyslipidemia |
| title | Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study |
| title_full | Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study |
| title_fullStr | Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study |
| title_full_unstemmed | Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study |
| title_short | Risk factors of developing non-arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study |
| title_sort | risk factors of developing non arteric ischemic optic neuropathy in patients with type 2 diabetes mellitus a single center retrospective cohort study |
| topic | non-arteric ischemic optic neuropathy systemic vascular disease type 2 diabetes mellitus hypertension dyslipidemia |
| url | http://ies.ijo.cn/en_publish/2025/2/20250213.pdf |
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