Spatial dimension of macrophage heterogeneity in liver diseases
The structural and cellular organisation of the liver has unique features that define it as both a metabolic and an immunological organ. Noteworthy, liver resident macrophages, named Kupffer cells, represent the most frequent tissue resident macrophage population in the human body. Nonetheless, on a...
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BMJ Publishing Group
2023-08-01
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| Series: | eGastroenterology |
| Online Access: | https://egastroenterology.bmj.com/content/1/1/e000003.full |
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| author | Adrien Guillot Frank Tacke |
| author_facet | Adrien Guillot Frank Tacke |
| author_sort | Adrien Guillot |
| collection | DOAJ |
| description | The structural and cellular organisation of the liver has unique features that define it as both a metabolic and an immunological organ. Noteworthy, liver resident macrophages, named Kupffer cells, represent the most frequent tissue resident macrophage population in the human body. Nonetheless, on acute or chronic tissue injury, Kupffer cells seem rather static and may undergo cell death, while the liver is massively infiltrated by circulating immune cells such as bone marrow-derived macrophages, also termed monocyte-derived macrophages, which drastically alter the hepatic immune landscape. Over the last decade, our knowledge on liver macrophage populations during homeostasis and liver diseases has greatly expanded. This particularly holds true in light of the recent fast-paced technological advances that brought novel dimensions to our knowledge, either in single-cell suspensions, in a two-dimensional plane or a three-dimensional space, or even in time-lapse (intravital) microscopy. This novel understanding goes from unravelling a previously underestimated macrophage diversity (eg, in terms of activation phenotype or cellular origins) to identifying spatially or temporally restricted responses that drive liver disease outcome. This review aims at providing insights into the most recent breakthroughs in our understanding of liver macrophage biology and its roles in liver (patho)physiology, in a four-dimensional perspective. |
| format | Article |
| id | doaj-art-e9dfe1eac44f4ed0a02847858cfbc47a |
| institution | Kabale University |
| issn | 2766-0125 2976-7296 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | eGastroenterology |
| spelling | doaj-art-e9dfe1eac44f4ed0a02847858cfbc47a2024-12-25T14:25:10ZengBMJ Publishing GroupeGastroenterology2766-01252976-72962023-08-011110.1136/egastro-2023-000003Spatial dimension of macrophage heterogeneity in liver diseasesAdrien Guillot0Frank Tacke1Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, GermanyDepartment of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, GermanyThe structural and cellular organisation of the liver has unique features that define it as both a metabolic and an immunological organ. Noteworthy, liver resident macrophages, named Kupffer cells, represent the most frequent tissue resident macrophage population in the human body. Nonetheless, on acute or chronic tissue injury, Kupffer cells seem rather static and may undergo cell death, while the liver is massively infiltrated by circulating immune cells such as bone marrow-derived macrophages, also termed monocyte-derived macrophages, which drastically alter the hepatic immune landscape. Over the last decade, our knowledge on liver macrophage populations during homeostasis and liver diseases has greatly expanded. This particularly holds true in light of the recent fast-paced technological advances that brought novel dimensions to our knowledge, either in single-cell suspensions, in a two-dimensional plane or a three-dimensional space, or even in time-lapse (intravital) microscopy. This novel understanding goes from unravelling a previously underestimated macrophage diversity (eg, in terms of activation phenotype or cellular origins) to identifying spatially or temporally restricted responses that drive liver disease outcome. This review aims at providing insights into the most recent breakthroughs in our understanding of liver macrophage biology and its roles in liver (patho)physiology, in a four-dimensional perspective.https://egastroenterology.bmj.com/content/1/1/e000003.full |
| spellingShingle | Adrien Guillot Frank Tacke Spatial dimension of macrophage heterogeneity in liver diseases eGastroenterology |
| title | Spatial dimension of macrophage heterogeneity in liver diseases |
| title_full | Spatial dimension of macrophage heterogeneity in liver diseases |
| title_fullStr | Spatial dimension of macrophage heterogeneity in liver diseases |
| title_full_unstemmed | Spatial dimension of macrophage heterogeneity in liver diseases |
| title_short | Spatial dimension of macrophage heterogeneity in liver diseases |
| title_sort | spatial dimension of macrophage heterogeneity in liver diseases |
| url | https://egastroenterology.bmj.com/content/1/1/e000003.full |
| work_keys_str_mv | AT adrienguillot spatialdimensionofmacrophageheterogeneityinliverdiseases AT franktacke spatialdimensionofmacrophageheterogeneityinliverdiseases |