Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue
The present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. U...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/1726848 |
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| author | Zhiguo Jiang Xiao-Feng Wang Guang H. Yue |
| author_facet | Zhiguo Jiang Xiao-Feng Wang Guang H. Yue |
| author_sort | Zhiguo Jiang |
| collection | DOAJ |
| description | The present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. Understanding activation relation between the subcortical structures and the M1 during prolonged motor performance should help delineate how central motor control network modulates acute perturbations at peripheral sensorimotor system such as muscle fatigue. Ten healthy subjects participated in the study and completed a 20-minute intermittent handgrip motor task at 50% of their maximal voluntary contraction (MVC) level. Quantile regression analyses were carried out to compare the FC between the contralateral (left) M1 and CB, BG, and TL in the minimal (beginning 100 s) versus significant (ending 100 s) fatigue stages. Widespread, statistically significant increases in FC were found in bilateral BG, CB, and TL with the left M1 during significant versus minimal fatigue stages. Our results imply that these subcortical nuclei are critical components in the motor control network and actively involved in modulating voluntary muscle fatigue, possibly, by working together with the M1 to strengthen the descending central command to prolong the motor performance. |
| format | Article |
| id | doaj-art-e9dd2c31faaf4524af279807f880a711 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e9dd2c31faaf4524af279807f880a7112025-08-20T02:21:54ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/17268481726848Strengthened Corticosubcortical Functional Connectivity during Muscle FatigueZhiguo Jiang0Xiao-Feng Wang1Guang H. Yue2Human Performance and Engineering Research, Kessler Foundation, 1199 Pleasant Valley Way, West Orange, NJ, USADepartment of Quantitative Health Science, The Cleveland Clinic, 9500 Euclid Avenue/JJN3, Cleveland, OH, USAHuman Performance and Engineering Research, Kessler Foundation, 1199 Pleasant Valley Way, West Orange, NJ, USAThe present study examined functional connectivity (FC) between functional MRI (fMRI) signals of the primary motor cortex (M1) and each of the three subcortical neural structures, cerebellum (CB), basal ganglia (BG), and thalamus (TL), during muscle fatigue using the quantile regression technique. Understanding activation relation between the subcortical structures and the M1 during prolonged motor performance should help delineate how central motor control network modulates acute perturbations at peripheral sensorimotor system such as muscle fatigue. Ten healthy subjects participated in the study and completed a 20-minute intermittent handgrip motor task at 50% of their maximal voluntary contraction (MVC) level. Quantile regression analyses were carried out to compare the FC between the contralateral (left) M1 and CB, BG, and TL in the minimal (beginning 100 s) versus significant (ending 100 s) fatigue stages. Widespread, statistically significant increases in FC were found in bilateral BG, CB, and TL with the left M1 during significant versus minimal fatigue stages. Our results imply that these subcortical nuclei are critical components in the motor control network and actively involved in modulating voluntary muscle fatigue, possibly, by working together with the M1 to strengthen the descending central command to prolong the motor performance.http://dx.doi.org/10.1155/2016/1726848 |
| spellingShingle | Zhiguo Jiang Xiao-Feng Wang Guang H. Yue Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue Neural Plasticity |
| title | Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue |
| title_full | Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue |
| title_fullStr | Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue |
| title_full_unstemmed | Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue |
| title_short | Strengthened Corticosubcortical Functional Connectivity during Muscle Fatigue |
| title_sort | strengthened corticosubcortical functional connectivity during muscle fatigue |
| url | http://dx.doi.org/10.1155/2016/1726848 |
| work_keys_str_mv | AT zhiguojiang strengthenedcorticosubcorticalfunctionalconnectivityduringmusclefatigue AT xiaofengwang strengthenedcorticosubcorticalfunctionalconnectivityduringmusclefatigue AT guanghyue strengthenedcorticosubcorticalfunctionalconnectivityduringmusclefatigue |