Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy
Bisphosphonates are currently the standard approach to managing bone disease in multiple myeloma. Bisphosphonates have high bone affinity that inhibits osteoclastic activity and additionally reduces the growth factors released from malignant or osteoblastic cells, thereby impairing abnormal bone rem...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2014/452418 |
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| _version_ | 1832557064550875136 |
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| author | Ichiro Tonogai Tomohiro Goto Daisuke Hamada Toshiyuki Iwame Shinji Yoshioka Takahiko Tsutsui Yuichiro Goda Hiroshi Egawa Koichi Sairyo |
| author_facet | Ichiro Tonogai Tomohiro Goto Daisuke Hamada Toshiyuki Iwame Shinji Yoshioka Takahiko Tsutsui Yuichiro Goda Hiroshi Egawa Koichi Sairyo |
| author_sort | Ichiro Tonogai |
| collection | DOAJ |
| description | Bisphosphonates are currently the standard approach to managing bone disease in multiple myeloma. Bisphosphonates have high bone affinity that inhibits osteoclastic activity and additionally reduces the growth factors released from malignant or osteoblastic cells, thereby impairing abnormal bone remodeling which leads to osteolysis. However, patients of multiple myeloma may be at a higher risk of atypical femoral fractures because the treatment for malignant myeloma requires notably higher cumulative doses of bisphosphonates. Here we present a patient with bilateral atypical femoral fractures and multiple myeloma treated with intravenous bisphosphonate therapy. |
| format | Article |
| id | doaj-art-e9dba7bd52554bfab3fb523323f6b37d |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-e9dba7bd52554bfab3fb523323f6b37d2025-02-03T05:43:43ZengWileyCase Reports in Orthopedics2090-67492090-67572014-01-01201410.1155/2014/452418452418Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate TherapyIchiro Tonogai0Tomohiro Goto1Daisuke Hamada2Toshiyuki Iwame3Shinji Yoshioka4Takahiko Tsutsui5Yuichiro Goda6Hiroshi Egawa7Koichi Sairyo8Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanDepartment of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, JapanBisphosphonates are currently the standard approach to managing bone disease in multiple myeloma. Bisphosphonates have high bone affinity that inhibits osteoclastic activity and additionally reduces the growth factors released from malignant or osteoblastic cells, thereby impairing abnormal bone remodeling which leads to osteolysis. However, patients of multiple myeloma may be at a higher risk of atypical femoral fractures because the treatment for malignant myeloma requires notably higher cumulative doses of bisphosphonates. Here we present a patient with bilateral atypical femoral fractures and multiple myeloma treated with intravenous bisphosphonate therapy.http://dx.doi.org/10.1155/2014/452418 |
| spellingShingle | Ichiro Tonogai Tomohiro Goto Daisuke Hamada Toshiyuki Iwame Shinji Yoshioka Takahiko Tsutsui Yuichiro Goda Hiroshi Egawa Koichi Sairyo Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy Case Reports in Orthopedics |
| title | Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy |
| title_full | Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy |
| title_fullStr | Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy |
| title_full_unstemmed | Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy |
| title_short | Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy |
| title_sort | bilateral atypical femoral fractures in a patient with multiple myeloma treated with intravenous bisphosphonate therapy |
| url | http://dx.doi.org/10.1155/2014/452418 |
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