Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation
Aim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving prop...
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«SILICEA-POLIGRAF» LLC
2006-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1199 |
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| author | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky |
| author_facet | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky |
| author_sort | I. G. Fomina |
| collection | DOAJ |
| description | Aim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving propafenone (450 mg/d) for 3 months, to prevent recurrent AF. To assess antiarrhythmic therapy effects on inotropic myocardial function, all participants underwent balanced radionuclide ventriculography at baseline; in patients with maintained sinus rhythm, it was repeated after 3 months of treatment. Results. In first 3 days after restoring sinus rhythm in recurrent AF patients, diastolic function dynamics was observed: significant reduction in 1/3 diastole filling and peak filling velocity. After 3 months of propafenone treatment, left ventricular (LF) 1/3 diastole filling (p<0.05), as well as LV and right ventricular (RV) filling peak velocity (p<0.05), significantly increased. Ejection fraction, systolic and volumic parameters of LV and RV stayed within the normal range and did not change significantly. After 3-month propafenone therapy, recurrent AF patients demonstrated significant increase in atrial input into LV diastole – from 17.1±5.7% to 22.1±6.5%, and RV diastole – from 17.3±5.1% to 21.1±6.2% (р<0.05). Conclusion. Propafenone therapy (450 mg/d) facilitated 3-month sinus rhythm maintenance in 77% patients with recurrent AF. The therapy did not affect LF and RV inotropic myocardial function. Maintaining sinus rhythm for 3 moths facilitated normalization of atrial contractility and ventricular diastolic dysfunction improvement. |
| format | Article |
| id | doaj-art-e9d632d0fac54459b1ded7564d320253 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2006-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-e9d632d0fac54459b1ded7564d3202532025-08-20T03:43:30Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-06-01534954911Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillationI. G. Fomina0A. I. Tarzimanova1A. V. Vetluzhsky2I.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 61. MoscowI.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 61. MoscowI.M. Sechenov Moscow Medical Academy, City Clinical Hospital No. 61. MoscowAim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving propafenone (450 mg/d) for 3 months, to prevent recurrent AF. To assess antiarrhythmic therapy effects on inotropic myocardial function, all participants underwent balanced radionuclide ventriculography at baseline; in patients with maintained sinus rhythm, it was repeated after 3 months of treatment. Results. In first 3 days after restoring sinus rhythm in recurrent AF patients, diastolic function dynamics was observed: significant reduction in 1/3 diastole filling and peak filling velocity. After 3 months of propafenone treatment, left ventricular (LF) 1/3 diastole filling (p<0.05), as well as LV and right ventricular (RV) filling peak velocity (p<0.05), significantly increased. Ejection fraction, systolic and volumic parameters of LV and RV stayed within the normal range and did not change significantly. After 3-month propafenone therapy, recurrent AF patients demonstrated significant increase in atrial input into LV diastole – from 17.1±5.7% to 22.1±6.5%, and RV diastole – from 17.3±5.1% to 21.1±6.2% (р<0.05). Conclusion. Propafenone therapy (450 mg/d) facilitated 3-month sinus rhythm maintenance in 77% patients with recurrent AF. The therapy did not affect LF and RV inotropic myocardial function. Maintaining sinus rhythm for 3 moths facilitated normalization of atrial contractility and ventricular diastolic dysfunction improvement.https://cardiovascular.elpub.ru/jour/article/view/1199atrial fibrillationpropafenoneheart inotropic functionatrial remodeling |
| spellingShingle | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation Кардиоваскулярная терапия и профилактика atrial fibrillation propafenone heart inotropic function atrial remodeling |
| title | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_full | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_fullStr | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_full_unstemmed | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_short | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_sort | propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| topic | atrial fibrillation propafenone heart inotropic function atrial remodeling |
| url | https://cardiovascular.elpub.ru/jour/article/view/1199 |
| work_keys_str_mv | AT igfomina propafenoneeffectoninotropicmyocardialfunctioninpatientswithrecurrentatralfibrillation AT aitarzimanova propafenoneeffectoninotropicmyocardialfunctioninpatientswithrecurrentatralfibrillation AT avvetluzhsky propafenoneeffectoninotropicmyocardialfunctioninpatientswithrecurrentatralfibrillation |