Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants
Abstract To assess intraocular pressure (IOP) changes and the development of ocular hypertension (OH) following pars plana vitrectomy (PPV), evaluating short- and long-term outcomes and risk factors. This is a retrospective study of 216 patients (432 eyes) who underwent primary unilateral PPV betwee...
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Nature Portfolio
2025-08-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12905-8 |
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| author | Ana Faria Pereira Pedro Marques-Couto Rita Teixeira-Martins Amândio Rocha-Sousa Pedro Alves-Faria Joana R. Araújo |
| author_facet | Ana Faria Pereira Pedro Marques-Couto Rita Teixeira-Martins Amândio Rocha-Sousa Pedro Alves-Faria Joana R. Araújo |
| author_sort | Ana Faria Pereira |
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| description | Abstract To assess intraocular pressure (IOP) changes and the development of ocular hypertension (OH) following pars plana vitrectomy (PPV), evaluating short- and long-term outcomes and risk factors. This is a retrospective study of 216 patients (432 eyes) who underwent primary unilateral PPV between April 2018 and July 2020, with ≥ 12 months of follow-up. IOP in vitrectomized and fellow eyes was analyzed preoperatively, at 3 months, and at final visit. OH was defined as the need for IOP-lowering medication; IOP was also analyzed as a continuous variable. Baseline and intraoperative factors were evaluated using cohort and matched case–control designs. Median follow-up was 28 months. Early and late OH occurred in 28.2% and 15.3% of vitrectomized eyes. Retinal detachment (RD) increased the risk of early OH fourfold (OR 4.16; p < 0.001). Higher preoperative IOP in the fellow eye predicted both early (OR 1.17; p = 0.003) and late OH (OR 1.18; p = 0.007). Postoperatively, vitrectomized eyes had higher IOP at all timepoints. Glaucoma developed in 6.5% of vitrectomized vs. 1.4% of fellow eyes (p = 0.008). PPV is associated with sustained IOP elevation and increased OH risk. RD and fellow eye IOP are relevant predictors. Long-term monitoring is essential to prevent glaucoma, especially in high-risk patients. |
| format | Article |
| id | doaj-art-e9d48fe0ca6d49d9be232493bdc6833b |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
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| spelling | doaj-art-e9d48fe0ca6d49d9be232493bdc6833b2025-08-20T03:04:34ZengNature PortfolioScientific Reports2045-23222025-08-011511910.1038/s41598-025-12905-8Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinantsAna Faria Pereira0Pedro Marques-Couto1Rita Teixeira-Martins2Amândio Rocha-Sousa3Pedro Alves-Faria4Joana R. Araújo5Department of Ophthalmology, Unidade Local de Saúde São JoãoDepartment of Ophthalmology, Unidade Local de Saúde São JoãoDepartment of Ophthalmology, Unidade Local de Saúde São JoãoDepartment of Ophthalmology, Unidade Local de Saúde São JoãoDepartment of Ophthalmology, Unidade Local de Saúde São JoãoDepartment of Ophthalmology, Unidade Local de Saúde São JoãoAbstract To assess intraocular pressure (IOP) changes and the development of ocular hypertension (OH) following pars plana vitrectomy (PPV), evaluating short- and long-term outcomes and risk factors. This is a retrospective study of 216 patients (432 eyes) who underwent primary unilateral PPV between April 2018 and July 2020, with ≥ 12 months of follow-up. IOP in vitrectomized and fellow eyes was analyzed preoperatively, at 3 months, and at final visit. OH was defined as the need for IOP-lowering medication; IOP was also analyzed as a continuous variable. Baseline and intraoperative factors were evaluated using cohort and matched case–control designs. Median follow-up was 28 months. Early and late OH occurred in 28.2% and 15.3% of vitrectomized eyes. Retinal detachment (RD) increased the risk of early OH fourfold (OR 4.16; p < 0.001). Higher preoperative IOP in the fellow eye predicted both early (OR 1.17; p = 0.003) and late OH (OR 1.18; p = 0.007). Postoperatively, vitrectomized eyes had higher IOP at all timepoints. Glaucoma developed in 6.5% of vitrectomized vs. 1.4% of fellow eyes (p = 0.008). PPV is associated with sustained IOP elevation and increased OH risk. RD and fellow eye IOP are relevant predictors. Long-term monitoring is essential to prevent glaucoma, especially in high-risk patients.https://doi.org/10.1038/s41598-025-12905-8VitrectomyOcular hypertensionGlaucoma |
| spellingShingle | Ana Faria Pereira Pedro Marques-Couto Rita Teixeira-Martins Amândio Rocha-Sousa Pedro Alves-Faria Joana R. Araújo Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants Scientific Reports Vitrectomy Ocular hypertension Glaucoma |
| title | Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants |
| title_full | Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants |
| title_fullStr | Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants |
| title_full_unstemmed | Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants |
| title_short | Effect of pars plana vitrectomy on early and long-term intraocular pressure and its determinants |
| title_sort | effect of pars plana vitrectomy on early and long term intraocular pressure and its determinants |
| topic | Vitrectomy Ocular hypertension Glaucoma |
| url | https://doi.org/10.1038/s41598-025-12905-8 |
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