Gastrointestinal Stromal Tumor in Pregnancy: A Case Report
Background. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and are diagnosed relatively seldom in pregnancy. Case. We describe a remarkable clinical course and long-term outcome, now nine years after first diagnosis, of a massive and metastatic,...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/456402 |
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| author | S. Scherjon W. F. Lam H. Gelderblom F. W. Jansen |
| author_facet | S. Scherjon W. F. Lam H. Gelderblom F. W. Jansen |
| author_sort | S. Scherjon |
| collection | DOAJ |
| description | Background. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and are diagnosed relatively seldom in pregnancy. Case. We describe a remarkable clinical course and long-term outcome, now nine years after first diagnosis, of a massive and metastatic, with a high malignancy grade GIST case, found in and treated from the first trimester of pregnancy onwards. Conclusion. GIST occurring during pregnancy is extremely rare. However, early diagnosis is important for optimal management. The recent better understanding of oncogenesis, the use of immunohistochemistry for differential diagnosis of GISTs, and the use of imatinib mesylate as the treatment of first choice are—as shown in this case—important for care of pregnant women with this type of malignancy. |
| format | Article |
| id | doaj-art-e9d27d7f918043cc8b898b84381116d8 |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-e9d27d7f918043cc8b898b84381116d82025-08-20T03:20:39ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/456402456402Gastrointestinal Stromal Tumor in Pregnancy: A Case ReportS. Scherjon0W. F. Lam1H. Gelderblom2F. W. Jansen3Department of Obstetrics, Leiden University Medical Center, P.O. Box 9600 (K6-26), 2300 RC Leiden, The NetherlandsDepartment of Obstetrics and Gynecology, IJsselland Ziekenhuis, Capelle a/d IJssel, The NetherlandsDepartment of Clinical Oncology, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Gynecology, Leiden University Medical Center, Leiden, The NetherlandsBackground. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and are diagnosed relatively seldom in pregnancy. Case. We describe a remarkable clinical course and long-term outcome, now nine years after first diagnosis, of a massive and metastatic, with a high malignancy grade GIST case, found in and treated from the first trimester of pregnancy onwards. Conclusion. GIST occurring during pregnancy is extremely rare. However, early diagnosis is important for optimal management. The recent better understanding of oncogenesis, the use of immunohistochemistry for differential diagnosis of GISTs, and the use of imatinib mesylate as the treatment of first choice are—as shown in this case—important for care of pregnant women with this type of malignancy.http://dx.doi.org/10.1155/2009/456402 |
| spellingShingle | S. Scherjon W. F. Lam H. Gelderblom F. W. Jansen Gastrointestinal Stromal Tumor in Pregnancy: A Case Report Case Reports in Medicine |
| title | Gastrointestinal Stromal Tumor in Pregnancy: A Case Report |
| title_full | Gastrointestinal Stromal Tumor in Pregnancy: A Case Report |
| title_fullStr | Gastrointestinal Stromal Tumor in Pregnancy: A Case Report |
| title_full_unstemmed | Gastrointestinal Stromal Tumor in Pregnancy: A Case Report |
| title_short | Gastrointestinal Stromal Tumor in Pregnancy: A Case Report |
| title_sort | gastrointestinal stromal tumor in pregnancy a case report |
| url | http://dx.doi.org/10.1155/2009/456402 |
| work_keys_str_mv | AT sscherjon gastrointestinalstromaltumorinpregnancyacasereport AT wflam gastrointestinalstromaltumorinpregnancyacasereport AT hgelderblom gastrointestinalstromaltumorinpregnancyacasereport AT fwjansen gastrointestinalstromaltumorinpregnancyacasereport |