Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region
Multiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result of drawing immune cells into central nervous...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2006-09-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3098 |
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| author | Yu. Yu. Orlova V. M. Alifirova N. V. Cherdyntseva P. A. Gervas |
| author_facet | Yu. Yu. Orlova V. M. Alifirova N. V. Cherdyntseva P. A. Gervas |
| author_sort | Yu. Yu. Orlova |
| collection | DOAJ |
| description | Multiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result of drawing immune cells into central nervous system. Mutation of CCR5 delta32 decreases functional activity of the appropriate receptor on cellular surface and thus can reduce migration of leucocytes into foci of injury. Aimed at studying the role of mutation in multiple sclerosis, we compared frequency of gene type CCR5 in peripheral mononuclears of 102 multiple sclerosis patients and in 136 healthy subjects. The results obtained allow to conclude that polymorphism of chemokine receptor gene CCR5del32 is not a leading factor in the susceptibility to multiple sclerosis in the studied population. |
| format | Article |
| id | doaj-art-e9d0765ce3f141308deb018efd349cd2 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2006-09-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-e9d0765ce3f141308deb018efd349cd22025-08-20T03:37:16ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842006-09-01539810410.20538/1682-0363-2006-3-98-1041756Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian regionYu. Yu. Orlova0V. M. Alifirova1N. V. Cherdyntseva2P. A. Gervas3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетНИИ онкологии ТНЦ СО РАМНMultiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result of drawing immune cells into central nervous system. Mutation of CCR5 delta32 decreases functional activity of the appropriate receptor on cellular surface and thus can reduce migration of leucocytes into foci of injury. Aimed at studying the role of mutation in multiple sclerosis, we compared frequency of gene type CCR5 in peripheral mononuclears of 102 multiple sclerosis patients and in 136 healthy subjects. The results obtained allow to conclude that polymorphism of chemokine receptor gene CCR5del32 is not a leading factor in the susceptibility to multiple sclerosis in the studied population.https://bulletin.ssmu.ru/jour/article/view/3098рассеянный склерозхемокиновый рецепторполиморфизмmultiple sclerosischemokine receptorpolymorphism |
| spellingShingle | Yu. Yu. Orlova V. M. Alifirova N. V. Cherdyntseva P. A. Gervas Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region Бюллетень сибирской медицины рассеянный склероз хемокиновый рецептор полиморфизм multiple sclerosis chemokine receptor polymorphism |
| title | Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region |
| title_full | Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region |
| title_fullStr | Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region |
| title_full_unstemmed | Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region |
| title_short | Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region |
| title_sort | polymorphism of chemokine receptor gene ccr5 in multiple sclerosis patients and in healthy subjects in the siberian region |
| topic | рассеянный склероз хемокиновый рецептор полиморфизм multiple sclerosis chemokine receptor polymorphism |
| url | https://bulletin.ssmu.ru/jour/article/view/3098 |
| work_keys_str_mv | AT yuyuorlova polymorphismofchemokinereceptorgeneccr5inmultiplesclerosispatientsandinhealthysubjectsinthesiberianregion AT vmalifirova polymorphismofchemokinereceptorgeneccr5inmultiplesclerosispatientsandinhealthysubjectsinthesiberianregion AT nvcherdyntseva polymorphismofchemokinereceptorgeneccr5inmultiplesclerosispatientsandinhealthysubjectsinthesiberianregion AT pagervas polymorphismofchemokinereceptorgeneccr5inmultiplesclerosispatientsandinhealthysubjectsinthesiberianregion |