Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes

Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes

Abstract Background Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate concentration, and co-regulate with cardiometab...

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Main Authors: Zhaoli Liu, Tania O. Crișan, Cancan Qi, Manoj Kumar Gupta, Xuan Liu, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Xun Jiang, Mohamad Ballan, L. Charlotte J. de Bree, Vera P. Mourits, Xu Gao, Andrea Baccarelli, Joel Schwartz, Frank Pessler, Carlos A. Guzmán, Yang Li, Mihai G. Netea, Leo A. B. Joosten, Cheng-Jian Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01044-w
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