Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report
Introduction: Disseminated histoplasmosis is a rare cause of granulomatous, cholestatic liver disease. It can also manifest with gastrointestinal (GI) tract involvement, usually with ulceration or mucosal thickening, but is rarely reported as a cause of mass lesions in the GI tract. It is...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-08-01
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| Series: | Case Reports in Gastroenterology |
| Online Access: | https://karger.com/article/doi/10.1159/000545824 |
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| author | Alice Leah Kerkham Martin David Weltman Zoe Jennings Han Liem |
| author_facet | Alice Leah Kerkham Martin David Weltman Zoe Jennings Han Liem |
| author_sort | Alice Leah Kerkham |
| collection | DOAJ |
| description |
Introduction: Disseminated histoplasmosis is a rare cause of granulomatous, cholestatic liver disease. It can also manifest with gastrointestinal (GI) tract involvement, usually with ulceration or mucosal thickening, but is rarely reported as a cause of mass lesions in the GI tract. It is also very rare for disseminated histoplasmosis to present in an immunocompetent host. Case Presentation: We present a case of cholestatic liver disease and a small bowel mass in a 50-year-old male that has not previously been described in an immunocompetent host. Conclusion: Timely diagnosis requires a high index of suspicion, particularly if there has been exposure to high-risk environments such as contaminated soils, as delayed diagnosis is associated with significant mortality. |
| format | Article |
| id | doaj-art-e9cac0c9a9114fbab52d9b12d2f07034 |
| institution | Kabale University |
| issn | 1662-0631 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj-art-e9cac0c9a9114fbab52d9b12d2f070342025-08-21T06:49:17ZengKarger PublishersCase Reports in Gastroenterology1662-06312025-08-0119156857310.1159/000545824Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case ReportAlice Leah KerkhamMartin David WeltmanZoe JenningsHan Liem Introduction: Disseminated histoplasmosis is a rare cause of granulomatous, cholestatic liver disease. It can also manifest with gastrointestinal (GI) tract involvement, usually with ulceration or mucosal thickening, but is rarely reported as a cause of mass lesions in the GI tract. It is also very rare for disseminated histoplasmosis to present in an immunocompetent host. Case Presentation: We present a case of cholestatic liver disease and a small bowel mass in a 50-year-old male that has not previously been described in an immunocompetent host. Conclusion: Timely diagnosis requires a high index of suspicion, particularly if there has been exposure to high-risk environments such as contaminated soils, as delayed diagnosis is associated with significant mortality. https://karger.com/article/doi/10.1159/000545824 |
| spellingShingle | Alice Leah Kerkham Martin David Weltman Zoe Jennings Han Liem Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report Case Reports in Gastroenterology |
| title | Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report |
| title_full | Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report |
| title_fullStr | Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report |
| title_full_unstemmed | Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report |
| title_short | Disseminated Histoplasmosis as a Cause of a Small Bowel Mass and Cholestatic Liver Injury in an Immunocompetent Host: A Case Report |
| title_sort | disseminated histoplasmosis as a cause of a small bowel mass and cholestatic liver injury in an immunocompetent host a case report |
| url | https://karger.com/article/doi/10.1159/000545824 |
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