Contemporary insights into neuroimmune interactions across development and aging
Initially considered distinct systems with independent physiological functions, recent evidence highlights the crucial role of active crosstalk between the nervous and immune systems in regulating critical physiological and neurological processes and immunological homeostasis. The identification of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1611124/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304147968393216 |
|---|---|
| author | Xin Yi Yeo Yunseon Choi Yeonhee Hong Hyuk Nam Kwon Hyuk Nam Kwon Sangyong Jung |
| author_facet | Xin Yi Yeo Yunseon Choi Yeonhee Hong Hyuk Nam Kwon Hyuk Nam Kwon Sangyong Jung |
| author_sort | Xin Yi Yeo |
| collection | DOAJ |
| description | Initially considered distinct systems with independent physiological functions, recent evidence highlights the crucial role of active crosstalk between the nervous and immune systems in regulating critical physiological and neurological processes and immunological homeostasis. The identification of a direct body-brain circuitry allowing the monitoring of peripheral inflammatory responses, a unique skull bone marrow source of immune cells to the central nervous system (CNS), and the physical interface of the blood-brain barrier with the meningeal system suggest direct intersystem interactions, which can be further modulated by the local tissue environment, allowing non-neurological factors to influence neurological outcomes and vice versa. While there is a recognized age-dependent decline in both neurological and immune system function, in part due to the natural accumulation of cellular defects and the development of chronic systemic inflammation, it is unclear if the pre-existing bidirectional feedback mechanisms between the neurological and peripheral immune system plays a role in shaping the system decline, beyond commonly investigated pathological conditions. In this review, we will explore the effect of aging on the bidirectional communication between the neurological and immunological systems and attempt to understand how the inevitable age-dependent alterations of the interaction may concurrently drive immunosenescence, normal neurological decline, and neuropathological progression. |
| format | Article |
| id | doaj-art-e9c6efcc569f43e686bf01d520336753 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e9c6efcc569f43e686bf01d5203367532025-08-20T03:55:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16111241611124Contemporary insights into neuroimmune interactions across development and agingXin Yi Yeo0Yunseon Choi1Yeonhee Hong2Hyuk Nam Kwon3Hyuk Nam Kwon4Sangyong Jung5Department of Medical Science, CHA University, Seongnam, Republic of KoreaDepartment of Medical Science, CHA University, Seongnam, Republic of KoreaDepartment of Medical Science, CHA University, Seongnam, Republic of KoreaSchool of Biological Science, University of Ulsan, Ulsan, Republic of KoreaBasic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, Republic of KoreaDepartment of Medical Science, CHA University, Seongnam, Republic of KoreaInitially considered distinct systems with independent physiological functions, recent evidence highlights the crucial role of active crosstalk between the nervous and immune systems in regulating critical physiological and neurological processes and immunological homeostasis. The identification of a direct body-brain circuitry allowing the monitoring of peripheral inflammatory responses, a unique skull bone marrow source of immune cells to the central nervous system (CNS), and the physical interface of the blood-brain barrier with the meningeal system suggest direct intersystem interactions, which can be further modulated by the local tissue environment, allowing non-neurological factors to influence neurological outcomes and vice versa. While there is a recognized age-dependent decline in both neurological and immune system function, in part due to the natural accumulation of cellular defects and the development of chronic systemic inflammation, it is unclear if the pre-existing bidirectional feedback mechanisms between the neurological and peripheral immune system plays a role in shaping the system decline, beyond commonly investigated pathological conditions. In this review, we will explore the effect of aging on the bidirectional communication between the neurological and immunological systems and attempt to understand how the inevitable age-dependent alterations of the interaction may concurrently drive immunosenescence, normal neurological decline, and neuropathological progression.https://www.frontiersin.org/articles/10.3389/fneur.2025.1611124/fullagingneuroimmune crosstalkimmunosenescenceneurological declineneurodegeneration |
| spellingShingle | Xin Yi Yeo Yunseon Choi Yeonhee Hong Hyuk Nam Kwon Hyuk Nam Kwon Sangyong Jung Contemporary insights into neuroimmune interactions across development and aging Frontiers in Neurology aging neuroimmune crosstalk immunosenescence neurological decline neurodegeneration |
| title | Contemporary insights into neuroimmune interactions across development and aging |
| title_full | Contemporary insights into neuroimmune interactions across development and aging |
| title_fullStr | Contemporary insights into neuroimmune interactions across development and aging |
| title_full_unstemmed | Contemporary insights into neuroimmune interactions across development and aging |
| title_short | Contemporary insights into neuroimmune interactions across development and aging |
| title_sort | contemporary insights into neuroimmune interactions across development and aging |
| topic | aging neuroimmune crosstalk immunosenescence neurological decline neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1611124/full |
| work_keys_str_mv | AT xinyiyeo contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging AT yunseonchoi contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging AT yeonheehong contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging AT hyuknamkwon contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging AT hyuknamkwon contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging AT sangyongjung contemporaryinsightsintoneuroimmuneinteractionsacrossdevelopmentandaging |