Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study
Atopic dermatitis is a chronic skin disease affecting quality of life, sleep, and mental health. Traditional evaluation methods focus on clinical assessments, but there is a growing need for tools that incorporate patient-reported outcomes (PROs). To evaluate the effectiveness of the Atopic Dermatit...
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Medical Journals Sweden
2025-02-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/40704 |
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| author | Hyun Ji Lee Yuri Woo Young Bok Lee Ji Hye Lee Jung Eun Kim Ji Hyun Lee Sang Hyun Cho |
| author_facet | Hyun Ji Lee Yuri Woo Young Bok Lee Ji Hye Lee Jung Eun Kim Ji Hyun Lee Sang Hyun Cho |
| author_sort | Hyun Ji Lee |
| collection | DOAJ |
| description | Atopic dermatitis is a chronic skin disease affecting quality of life, sleep, and mental health. Traditional evaluation methods focus on clinical assessments, but there is a growing need for tools that incorporate patient-reported outcomes (PROs). To evaluate the effectiveness of the Atopic Dermatitis Control Tool (ADCT) in assessing disease severity in patients with moderate to severe atopic dermatitis and to compare the efficacy of systemic immunosuppressants and dupilumab in patients with moderate to severe atopic dermatitis. A prospective, observational study was conducted across seven centres in Korea, involving 112 patients with moderate to severe atopic dermatitis. The ADCT, Eczema Area and Severity Index (EASI), and Dermatology Life Quality Index (DLQI) were used for assessing atopic dermatitis severity. In addition, the study assessed the effectiveness of immunosuppressants and dupilumab over the course of one year. The study found significant correlations between ADCT scores and other severity measures (EASI, DLQI). The correlation coefficients were 0.54 (p < 0.0001) for ADCT vs EASI and 0.83 (p < 0.0001) for ADCT vs DLQI. Furthermore, patients treated with dupilumab exhibited greater improvement compared with those on cyclosporine, as measured by the ADCT (adjusted OR [95% CI]); 6.98 [2.49, 19.58]). The ADCT effectively captures subjective aspects compared with the EASI and can be used practically and effectively in clinical settings of atopic dermatitis.
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| format | Article |
| id | doaj-art-e9c6c88c45a54aeaafffafe469320030 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-e9c6c88c45a54aeaafffafe4693200302025-02-12T08:43:18ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-02-0110510.2340/actadv.v105.40704Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective StudyHyun Ji Lee0Yuri Woo1Young Bok Lee2Ji Hye Lee3Jung Eun Kim4Ji Hyun Lee5Sang Hyun Cho6Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaAtopic dermatitis is a chronic skin disease affecting quality of life, sleep, and mental health. Traditional evaluation methods focus on clinical assessments, but there is a growing need for tools that incorporate patient-reported outcomes (PROs). To evaluate the effectiveness of the Atopic Dermatitis Control Tool (ADCT) in assessing disease severity in patients with moderate to severe atopic dermatitis and to compare the efficacy of systemic immunosuppressants and dupilumab in patients with moderate to severe atopic dermatitis. A prospective, observational study was conducted across seven centres in Korea, involving 112 patients with moderate to severe atopic dermatitis. The ADCT, Eczema Area and Severity Index (EASI), and Dermatology Life Quality Index (DLQI) were used for assessing atopic dermatitis severity. In addition, the study assessed the effectiveness of immunosuppressants and dupilumab over the course of one year. The study found significant correlations between ADCT scores and other severity measures (EASI, DLQI). The correlation coefficients were 0.54 (p < 0.0001) for ADCT vs EASI and 0.83 (p < 0.0001) for ADCT vs DLQI. Furthermore, patients treated with dupilumab exhibited greater improvement compared with those on cyclosporine, as measured by the ADCT (adjusted OR [95% CI]); 6.98 [2.49, 19.58]). The ADCT effectively captures subjective aspects compared with the EASI and can be used practically and effectively in clinical settings of atopic dermatitis. https://medicaljournalssweden.se/actadv/article/view/40704atopic dermatitisAtopic Dermatitis Control Tooldupilumabcyclosporine |
| spellingShingle | Hyun Ji Lee Yuri Woo Young Bok Lee Ji Hye Lee Jung Eun Kim Ji Hyun Lee Sang Hyun Cho Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study Acta Dermato-Venereologica atopic dermatitis Atopic Dermatitis Control Tool dupilumab cyclosporine |
| title | Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study |
| title_full | Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study |
| title_fullStr | Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study |
| title_full_unstemmed | Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study |
| title_short | Evaluating the Real-World Effectiveness of Systemic Treatments in Atopic Dermatitis Using the Atopic Dermatitis Control Tool (ADCT): A Multi-Centre, Prospective Study |
| title_sort | evaluating the real world effectiveness of systemic treatments in atopic dermatitis using the atopic dermatitis control tool adct a multi centre prospective study |
| topic | atopic dermatitis Atopic Dermatitis Control Tool dupilumab cyclosporine |
| url | https://medicaljournalssweden.se/actadv/article/view/40704 |
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