Antimicrobial Sponge: A Polyvinyl Alcohol, Tannic Acid and Curcumin-Loaded Nanolignin Hydrogel Composite Scaffold
Materials with antimicrobial properties and high adsorption capabilities are crucial for managing exudate in post-surgical cases. However, achieving both properties simultaneously remains a challenge. In this study, we first synthesized curcumin-loaded organosolv lignin nanoparticles (Lig-Cur Nps) u...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/3/168 |
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| Summary: | Materials with antimicrobial properties and high adsorption capabilities are crucial for managing exudate in post-surgical cases. However, achieving both properties simultaneously remains a challenge. In this study, we first synthesized curcumin-loaded organosolv lignin nanoparticles (Lig-Cur Nps) using a solvent-shifting approach in a continuous flow reactor. These Lig-Cur NPs were then dispersed in a polyvinyl alcohol (PVA) solution. The PVA-Lig-Cur NP colloidal suspension was further crosslinked with tannic acid (TA) through hydrogen bonding interactions. A simple freeze–thaw cycle of the PVA-Lig-Cur NP suspension with TA resulted in the formation of a stable gel, which was then lyophilized to fabricate the PVA-Lig-Cur-TA hydrogel scaffold. This scaffold features an interconnected microporous network with a swelling percentage of 800%, enabling the rapid adsorption of exudates. Its excellent properties and antimicrobial efficacy against <i>Staphylococcus aureus</i>, a bacterium commonly found on the skin, and <i>Pseudomonas aeruginosa</i> highlight its potential to effectively remove exudates while preventing bacterial colonization. |
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| ISSN: | 2310-2861 |