Differential expression of PPARγ by pioglitazone and telmisartan causes effect of disparity on mTORC2-mediated cell proliferation and migration

Differential expression of PPARγ by pioglitazone and telmisartan causes effect of disparity on mTORC2-mediated cell proliferation and migration

Abstract Excessive cell proliferation and migration of vascular smooth muscle cells (VSMCs) exacerbate atherosclerotic plaque formation. Peroxisome proliferation-activated receptor gamma (PPARγ) has an atheroprotective effect by inhibiting foam cell formation in macrophages. However, the anti-prolif...

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Bibliographic Details
Main Authors: Seul Gi Kim, Jin Young Sung, So-Young Park, Hyoung Chul Choi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Atherosclerosis
Full agonist
Partial agonist
PPARγ
mTORC2
Vascular smooth muscle cell
Online Access:https://doi.org/10.1038/s41598-025-93320-x
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