The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach

Seasonality and dependence of age and sex is an important question in the development of ulcer of the stomach. Melatonin has an important place among the hormones that are involved in the formation of ulcer of the gastric mucosa. Aim. In order to establish the relationship between the levels of m...

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Main Authors: V. V. Hnatiuk, N. M. Kononenko
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2015-08-01
Series:Patologìâ
Subjects:
Online Access:http://pat.zsmu.edu.ua/article/view/48622/44810
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author V. V. Hnatiuk
N. M. Kononenko
author_facet V. V. Hnatiuk
N. M. Kononenko
author_sort V. V. Hnatiuk
collection DOAJ
description Seasonality and dependence of age and sex is an important question in the development of ulcer of the stomach. Melatonin has an important place among the hormones that are involved in the formation of ulcer of the gastric mucosa. Aim. In order to establish the relationship between the levels of melatonin and testosterone in ulcerative lesions of the stomach in male rats of different ages their level in the blood serum was studied by enzyme immunoassay ELISA. Methods and results. It was found that against the background of gastric ulceration a significant increase in melatonin levels and decrease in serum testosterone occur, most expressed in rats aged 9 months. Conclusion. The obtained results indicate the presence of the relationship between melatonin and testosterone levels in both normal and pathological conditions.
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publisher Zaporizhzhia State Medical and Pharmaceutical University
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spelling doaj-art-e9acb02741494ab5b3b545687d9372dc2025-08-20T02:21:57ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372015-08-012313410.14739/2310-1237.2015.2.48622The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomachV. V. HnatiukN. M. KononenkoSeasonality and dependence of age and sex is an important question in the development of ulcer of the stomach. Melatonin has an important place among the hormones that are involved in the formation of ulcer of the gastric mucosa. Aim. In order to establish the relationship between the levels of melatonin and testosterone in ulcerative lesions of the stomach in male rats of different ages their level in the blood serum was studied by enzyme immunoassay ELISA. Methods and results. It was found that against the background of gastric ulceration a significant increase in melatonin levels and decrease in serum testosterone occur, most expressed in rats aged 9 months. Conclusion. The obtained results indicate the presence of the relationship between melatonin and testosterone levels in both normal and pathological conditions.http://pat.zsmu.edu.ua/article/view/48622/44810MelatoninTestosteroneUlcerStomachMaleRats
spellingShingle V. V. Hnatiuk
N. M. Kononenko
The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
Patologìâ
Melatonin
Testosterone
Ulcer
Stomach
Male
Rats
title The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
title_full The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
title_fullStr The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
title_full_unstemmed The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
title_short The relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
title_sort relationship between the levels of melatonin and testosterone in male rats of different ages with ulcer of the stomach
topic Melatonin
Testosterone
Ulcer
Stomach
Male
Rats
url http://pat.zsmu.edu.ua/article/view/48622/44810
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AT nmkononenko therelationshipbetweenthelevelsofmelatoninandtestosteroneinmaleratsofdifferentageswithulcerofthestomach
AT vvhnatiuk relationshipbetweenthelevelsofmelatoninandtestosteroneinmaleratsofdifferentageswithulcerofthestomach
AT nmkononenko relationshipbetweenthelevelsofmelatoninandtestosteroneinmaleratsofdifferentageswithulcerofthestomach