Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia
Purpose. Obesity is a risk factor for severe coronavirus disease 2019 (COVID-19). Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/9908450 |
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| author | Federica Tonon Stefano Di Bella Fabiola Giudici Verena Zerbato Ludovica Segat Raffaella Koncan Andrea Misin Barbara Toffoli Pierlanfranco D’Agaro Roberto Luzzati Bruno Fabris Stella Bernardi |
| author_facet | Federica Tonon Stefano Di Bella Fabiola Giudici Verena Zerbato Ludovica Segat Raffaella Koncan Andrea Misin Barbara Toffoli Pierlanfranco D’Agaro Roberto Luzzati Bruno Fabris Stella Bernardi |
| author_sort | Federica Tonon |
| collection | DOAJ |
| description | Purpose. Obesity is a risk factor for severe coronavirus disease 2019 (COVID-19). Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia and to assess disease severity. Methods. We conducted an observational case-control study, with a prospective design, and recruited patients with diagnosis of COVID-19 pneumonia (n = 48) and healthy controls (n = 36), who were matched by age, sex, and BMI. Leptin, adiponectin, IL-6, and TNF-α were measured by ELISA. Results. Patients with COVID-19 pneumonia had higher levels of leptin, lower adiponectin/leptin (Adpn/Lep) ratio, and higher expression of IL-6. Leptin had an acceptable discriminatory accuracy for COVID-19 pneumonia in patients with BMI >30 (AUC 0.74 [0.58, 0.90]) with a cutoff of 7852 pg/mL and it was associated with maximum respiratory support. By contrast, Adpn/Lep had an excellent discriminatory accuracy for COVID-19 pneumonia in patients with BMI <25 (AUC 0.9 [0.74, 1.06]) with a cutoff of 2.23. Conclusion. Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia. |
| format | Article |
| id | doaj-art-e9aa600cba484c10b65e0380eb93e15e |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e9aa600cba484c10b65e0380eb93e15e2025-02-03T05:50:31ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/9908450Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 PneumoniaFederica Tonon0Stefano Di Bella1Fabiola Giudici2Verena Zerbato3Ludovica Segat4Raffaella Koncan5Andrea Misin6Barbara Toffoli7Pierlanfranco D’Agaro8Roberto Luzzati9Bruno Fabris10Stella Bernardi11Department of Medical Surgical and Health SciencesDepartment of Medical Surgical and Health SciencesGustave-RoussySC Malattie Infettive, Ospedale MaggioreU.C.O. Igiene e Sanità Pubblica, Ospedale MaggioreDepartment of Medical Surgical and Health SciencesSC Malattie Infettive, Ospedale MaggioreDepartment of Medical Surgical and Health SciencesDepartment of Medical Surgical and Health SciencesDepartment of Medical Surgical and Health SciencesDepartment of Medical Surgical and Health SciencesDepartment of Medical Surgical and Health SciencesPurpose. Obesity is a risk factor for severe coronavirus disease 2019 (COVID-19). Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia and to assess disease severity. Methods. We conducted an observational case-control study, with a prospective design, and recruited patients with diagnosis of COVID-19 pneumonia (n = 48) and healthy controls (n = 36), who were matched by age, sex, and BMI. Leptin, adiponectin, IL-6, and TNF-α were measured by ELISA. Results. Patients with COVID-19 pneumonia had higher levels of leptin, lower adiponectin/leptin (Adpn/Lep) ratio, and higher expression of IL-6. Leptin had an acceptable discriminatory accuracy for COVID-19 pneumonia in patients with BMI >30 (AUC 0.74 [0.58, 0.90]) with a cutoff of 7852 pg/mL and it was associated with maximum respiratory support. By contrast, Adpn/Lep had an excellent discriminatory accuracy for COVID-19 pneumonia in patients with BMI <25 (AUC 0.9 [0.74, 1.06]) with a cutoff of 2.23. Conclusion. Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.http://dx.doi.org/10.1155/2022/9908450 |
| spellingShingle | Federica Tonon Stefano Di Bella Fabiola Giudici Verena Zerbato Ludovica Segat Raffaella Koncan Andrea Misin Barbara Toffoli Pierlanfranco D’Agaro Roberto Luzzati Bruno Fabris Stella Bernardi Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia International Journal of Endocrinology |
| title | Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia |
| title_full | Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia |
| title_fullStr | Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia |
| title_full_unstemmed | Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia |
| title_short | Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia |
| title_sort | discriminatory value of adiponectin to leptin ratio for covid 19 pneumonia |
| url | http://dx.doi.org/10.1155/2022/9908450 |
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