Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor
Abstract Patients of type 2 diabetes mellitus (T2DM) were grouped into subtypes by a symptom-based diagnostic system of the traditional Chinese medicine for detecting metabolomic information that would otherwise be lost due to the high degree of variations in clinical samples. LC/MS-based metabolomi...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-03215-0 |
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| author | Tianyichen Xiao Caiming Wu Yuxuan Huang Fangping Zheng Nafen Li Weihong Yan Chengyao Li Qida He Wenbin Hong Siqi Wu Yulong Li Songqing Wang Lei Zhang Changqin Liu Tianwei Lin Xueqin Chen |
| author_facet | Tianyichen Xiao Caiming Wu Yuxuan Huang Fangping Zheng Nafen Li Weihong Yan Chengyao Li Qida He Wenbin Hong Siqi Wu Yulong Li Songqing Wang Lei Zhang Changqin Liu Tianwei Lin Xueqin Chen |
| author_sort | Tianyichen Xiao |
| collection | DOAJ |
| description | Abstract Patients of type 2 diabetes mellitus (T2DM) were grouped into subtypes by a symptom-based diagnostic system of the traditional Chinese medicine for detecting metabolomic information that would otherwise be lost due to the high degree of variations in clinical samples. LC/MS-based metabolomic tools were employed to identify distinct metabolomic features in T2DM patients in one of the subtypes in the symptom-based diagnostic system. Several of the affected metabolic pathways could be ameliorated by the combined treatment of metformin and DPP4 inhibitor, except the taurine/hypotaurine metabolic pathway. It was possible that modulating the taurine/hypotaurine metabolism in the combined treatment with metformin and DPP4 inhibitor would enhance the therapeutic effects. To this end, a mouse diabetic model was treated with taurine in addition to metformin and DPP4 inhibitor. Indeed supplementing taurine during the combined treatment led to improvements in various indicators of the disorder such as those for the fatty acid and glucose metabolisms. It could be concluded that taurine was a useful supplement for treating T2DM with metformin and DPP4 inhibitor. |
| format | Article |
| id | doaj-art-e9a997bc3bd943139612e0fd94d19a2e |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-e9a997bc3bd943139612e0fd94d19a2e2025-08-20T02:34:14ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-03215-0Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitorTianyichen Xiao0Caiming Wu1Yuxuan Huang2Fangping Zheng3Nafen Li4Weihong Yan5Chengyao Li6Qida He7Wenbin Hong8Siqi Wu9Yulong Li10Songqing Wang11Lei Zhang12Changqin Liu13Tianwei Lin14Xueqin Chen15State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityDepartment of Endocrinology and Diabetes and Fujian Province Key Laboratory of Diabetes Translational Medicine, School of Medicine, The First Affiliated Hospital of Xiamen UniversityState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-Province Joint Engineering Laboratory of Targeted Drugs From Natural Products, School of Life Sciences, Xiamen UniversityXiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen UniversityAbstract Patients of type 2 diabetes mellitus (T2DM) were grouped into subtypes by a symptom-based diagnostic system of the traditional Chinese medicine for detecting metabolomic information that would otherwise be lost due to the high degree of variations in clinical samples. LC/MS-based metabolomic tools were employed to identify distinct metabolomic features in T2DM patients in one of the subtypes in the symptom-based diagnostic system. Several of the affected metabolic pathways could be ameliorated by the combined treatment of metformin and DPP4 inhibitor, except the taurine/hypotaurine metabolic pathway. It was possible that modulating the taurine/hypotaurine metabolism in the combined treatment with metformin and DPP4 inhibitor would enhance the therapeutic effects. To this end, a mouse diabetic model was treated with taurine in addition to metformin and DPP4 inhibitor. Indeed supplementing taurine during the combined treatment led to improvements in various indicators of the disorder such as those for the fatty acid and glucose metabolisms. It could be concluded that taurine was a useful supplement for treating T2DM with metformin and DPP4 inhibitor.https://doi.org/10.1038/s41598-025-03215-0TaurineMetforminDPP4 inhibitorType 2 diabetes mellitusSyndrome differentiation |
| spellingShingle | Tianyichen Xiao Caiming Wu Yuxuan Huang Fangping Zheng Nafen Li Weihong Yan Chengyao Li Qida He Wenbin Hong Siqi Wu Yulong Li Songqing Wang Lei Zhang Changqin Liu Tianwei Lin Xueqin Chen Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor Scientific Reports Taurine Metformin DPP4 inhibitor Type 2 diabetes mellitus Syndrome differentiation |
| title | Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor |
| title_full | Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor |
| title_fullStr | Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor |
| title_full_unstemmed | Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor |
| title_short | Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor |
| title_sort | taurine as a supplement for treating type ii diabetes mellitus with metformin and dpp4 inhibitor |
| topic | Taurine Metformin DPP4 inhibitor Type 2 diabetes mellitus Syndrome differentiation |
| url | https://doi.org/10.1038/s41598-025-03215-0 |
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