Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic

Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic

Abstract MicroRNA‐10b (miR‐10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition strongly impairs proliferation and survival of cultured glioma cells, including glioma‐initiating stem‐like cells (GSC)....

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Bibliographic Details
Main Authors: Nadiya M Teplyuk, Erik J Uhlmann, Galina Gabriely, Natalia Volfovsky, Yang Wang, Jian Teng, Priya Karmali, Eric Marcusson, Merlene Peter, Athul Mohan, Yevgenya Kraytsberg, Ron Cialic, E Antonio Chiocca, Jakub Godlewski, Bakhos Tannous, Anna M Krichevsky
Format: Article
Language:English
Published: Springer Nature 2016-02-01
Series:EMBO Molecular Medicine
Subjects:
alternative splicing
brain tumor
microRNA
oligonucleotide therapeutics
stem cells
Online Access:https://doi.org/10.15252/emmm.201505495
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