Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study
ABSTRACT Background To date, limited research has compared the systemic comorbidities of primary scarring alopecia types. Such research may provide insight into shared disease mechanisms, elucidate novel pathways for therapeutics, and identify those most at risk of comorbidities. Objectives To evalu...
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Wiley
2025-06-01
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| Series: | JEADV Clinical Practice |
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| Online Access: | https://doi.org/10.1002/jvc2.70015 |
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| author | Arielle Carolina Mora Hurtado Sarah Gonzalez Nicole C. Syder Arthur Manasyan Tiana Thompson Lucy Harvey Jack Rodman Nada Elbuluk |
| author_facet | Arielle Carolina Mora Hurtado Sarah Gonzalez Nicole C. Syder Arthur Manasyan Tiana Thompson Lucy Harvey Jack Rodman Nada Elbuluk |
| author_sort | Arielle Carolina Mora Hurtado |
| collection | DOAJ |
| description | ABSTRACT Background To date, limited research has compared the systemic comorbidities of primary scarring alopecia types. Such research may provide insight into shared disease mechanisms, elucidate novel pathways for therapeutics, and identify those most at risk of comorbidities. Objectives To evaluate the prevalences of systemic comorbidities among scarring alopecia types and compare the prevalence of these comorbidities with national United States prevalence. Methods A retrospective chart review was conducted investigating the systemic comorbidities in patients with scarring alopecia seen at public and private dermatology clinics in Los Angeles between 2018 and 2022. Results A total of 240 patients were identified. Compared to other scarring alopecia types, patients with central centrifugal cicatricial alopecia (CCCA) had an increased risk for concomitant traction alopecia (OR 13.98, p < 0.001), concomitant androgenetic alopecia (OR 3.40, p < 0.001), and vitamin D deficiency (OR 1.97, p = 0.039). Compared to the general US population, patients with scarring alopecia, including CCCA and lichen planopilaris/frontal fibrosing alopecia, had a higher prevalence of vitamin D deficiency, metabolic syndrome, depression, anxiety, thyroid disease, uterine fibroids, anemia, atopy, androgenetic alopecia, and breast cancer. Conclusions Larger, prospective, population‐based studies involving diverse patient groups are needed to differentiate the rates of comorbidities across scarring alopecia types. Dermatologists should consider a thorough review of systems in their patients with scarring alopecia to screen for associated comorbidities, encourage patients to be up to date with age‐appropriate screenings, and consider treatment plans that treat associated dermatologic comorbidities along with the primary scarring alopecia. |
| format | Article |
| id | doaj-art-e9a52d8150984608ab36b0fa278ad411 |
| institution | OA Journals |
| issn | 2768-6566 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | JEADV Clinical Practice |
| spelling | doaj-art-e9a52d8150984608ab36b0fa278ad4112025-08-20T02:07:05ZengWileyJEADV Clinical Practice2768-65662025-06-014248249410.1002/jvc2.70015Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional StudyArielle Carolina Mora Hurtado0Sarah Gonzalez1Nicole C. Syder2Arthur Manasyan3Tiana Thompson4Lucy Harvey5Jack Rodman6Nada Elbuluk7University of Wisconsin School of Medicine and Public Health Madison Wisconsin USAWayne State University School of Medicine Detroit Michigan USADepartment of Dermatology University of California San Franscisco San Franscisco California USAUniversity of Southern California Keck School of Medicine Los Angeles California USAUniversity of Southern California Keck School of Medicine Los Angeles California USAUniversity of Southern California Keck School of Medicine Los Angeles California USASouthern California Clinical and Translational Sciences Institute Los Angeles California USADepartment of Dermatology University of Southern California Keck School of Medicine Los Angeles California USAABSTRACT Background To date, limited research has compared the systemic comorbidities of primary scarring alopecia types. Such research may provide insight into shared disease mechanisms, elucidate novel pathways for therapeutics, and identify those most at risk of comorbidities. Objectives To evaluate the prevalences of systemic comorbidities among scarring alopecia types and compare the prevalence of these comorbidities with national United States prevalence. Methods A retrospective chart review was conducted investigating the systemic comorbidities in patients with scarring alopecia seen at public and private dermatology clinics in Los Angeles between 2018 and 2022. Results A total of 240 patients were identified. Compared to other scarring alopecia types, patients with central centrifugal cicatricial alopecia (CCCA) had an increased risk for concomitant traction alopecia (OR 13.98, p < 0.001), concomitant androgenetic alopecia (OR 3.40, p < 0.001), and vitamin D deficiency (OR 1.97, p = 0.039). Compared to the general US population, patients with scarring alopecia, including CCCA and lichen planopilaris/frontal fibrosing alopecia, had a higher prevalence of vitamin D deficiency, metabolic syndrome, depression, anxiety, thyroid disease, uterine fibroids, anemia, atopy, androgenetic alopecia, and breast cancer. Conclusions Larger, prospective, population‐based studies involving diverse patient groups are needed to differentiate the rates of comorbidities across scarring alopecia types. Dermatologists should consider a thorough review of systems in their patients with scarring alopecia to screen for associated comorbidities, encourage patients to be up to date with age‐appropriate screenings, and consider treatment plans that treat associated dermatologic comorbidities along with the primary scarring alopecia.https://doi.org/10.1002/jvc2.70015central centrifugal cicatricial alopecia (CCCA)comorbiditiesfrontal fibrosing alopecia (FFA)lichen planopilaris (LPP)scarring alopecia |
| spellingShingle | Arielle Carolina Mora Hurtado Sarah Gonzalez Nicole C. Syder Arthur Manasyan Tiana Thompson Lucy Harvey Jack Rodman Nada Elbuluk Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study JEADV Clinical Practice central centrifugal cicatricial alopecia (CCCA) comorbidities frontal fibrosing alopecia (FFA) lichen planopilaris (LPP) scarring alopecia |
| title | Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study |
| title_full | Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study |
| title_fullStr | Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study |
| title_full_unstemmed | Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study |
| title_short | Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study |
| title_sort | comorbidities of primary scarring alopecias a retrospective multi site cross sectional study |
| topic | central centrifugal cicatricial alopecia (CCCA) comorbidities frontal fibrosing alopecia (FFA) lichen planopilaris (LPP) scarring alopecia |
| url | https://doi.org/10.1002/jvc2.70015 |
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