Frk positively regulates innate antiviral immunity by phosphorylating TBK1

Frk positively regulates innate antiviral immunity by phosphorylating TBK1

Type I interferons (IFN-I) are crucial for the initial defense against viral infections. TBK1 serves as a key regulator in the production of IFN-I, with its phosphorylation being essential for the regulation of its activity. However, the regulatory mechanisms governing its activation remain incomple...

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Bibliographic Details
Main Authors: Xiaomei Zhang, Ying You, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Xiaohua Wen, Congcong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Microbiology
Subjects:
macrophages
Frk
TBK1
phosphorylation
IFN-I
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1525648/full
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