Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes

Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes

ABSTRACT Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. The bacteria replicate in epithelial cells from which they take up sphingolipids (SL) and incorporate them into the chlamydial membrane and the vacuole (termed inclusion)...

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Main Authors: Adriana Moldovan, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, David Komla Kessie, Marcel Rühling, Kathrin Stelzner, Regina Tschertok, Louise Kersting, Julian Fink, Jürgen Seibel, Burkhard Kleuser, Thomas Rudel
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
sphingolipids
Chlamydia
macrophage
neutrophil
phagocyte
sphingosine kinase 1
Online Access:https://journals.asm.org/doi/10.1128/mbio.03981-24
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