Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells

Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells

Both hepatitis B virus (HBV), an hepadnavirus with a DNA genome, and hepatitis A virus (HAV), a picornavirus, require the TRAMP-like host ZCCHC14-TENT4 complex for efficient replication. However, whereas HBV requires the nucleotidyltransferase activity of TENT4 to extend and stabilize the 3′ poly(A)...

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Bibliographic Details
Main Authors: You Li, Ankit Gupta, Brian N. Papas, David Aponte-Diaz, Jayden M. Harris, Ichiro Misumi, Jason K. Whitmire, Craig E. Cameron, Marcos Morgan, Stanley M. Lemon
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Viruses
Subjects:
nanopore sequencing
hepatovirus
picornavirus
terminal nucleotidyltransferase
ZCCHC14
PAPD5/7
Online Access:https://www.mdpi.com/1999-4915/17/5/665
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