Impact of cerebrospinal fluid leukocyte infiltration and activated neuroimmune mediators on survival with HIV-associated cryptococcal meningitis.

Impact of cerebrospinal fluid leukocyte infiltration and activated neuroimmune mediators on survival with HIV-associated cryptococcal meningitis.

<h4>Introduction</h4>Cryptococcal meningitis remains a prominent cause of death in persons with advanced HIV disease. CSF leukocyte infiltration predicts survival at 18 weeks; however, how CSF immune response relates to CSF leukocyte infiltration is unknown.<h4>Methods</h4>We...

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Main Authors: Samuel Okurut, David R Boulware, Yukari C Manabe, Lillian Tugume, Caleb P Skipper, Kenneth Ssebambulidde, Joshua Rhein, Abdu K Musubire, Andrew Akampurira, Elizabeth C Okafor, Joseph O Olobo, Edward N Janoff, David B Meya, for ASTRO Trial Team
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012873
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